The Perpendicular Orientation of Amphotericin B Methyl Ester in Hydrated Lipid Bilayers Supports the Barrel-Stave Model.
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DOI: 10.1021/acs.biochem.9b00180
Abstract: The clinically important antibiotic amphotericin B (AmB) is a membrane-active natural product that targets membrane sterol. The antimicrobial activity of AmB is generally attributed to its membrane permeabilization, which occurs when a pore is formed… read more here.
Keywords: supports barrel; barrel stave; stave model; amb ... See more keywords