De Novo-Designed α-Helical Barrels as Receptors for Small Molecules.
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DOI: 10.1021/acssynbio.8b00225
Abstract: We describe de novo-designed α-helical barrels (αHBs) that bind and discriminate between lipophilic biologically active molecules. αHBs have five or more α-helices arranged around central hydrophobic channels the diameters of which scale with oligomer state.… read more here.
Keywords: barrels receptors; receptors small; novo designed; small molecules ... See more keywords