Investigation of the Transporting Behavior of Framework DNA Nano‐Devices Across the Artificial Blood‐Brain Barrier (BBB)
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200459
Abstract: This study focused on exploring the ability of self‐assembled DNA frameworks to cross the blood‐brain barrier (BBB). We designed and assembled a series of DNA origami structures with equal quantity of nucleic acid materials but… read more here.
Keywords: blood brain; barrier bbb; brain barrier; dna ... See more keywords
Prediction of the Blood-Brain Barrier (BBB) Permeability of Chemicals Based on Machine-Learning and Ensemble Methods.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00343
Abstract: The ability of chemicals to enter the blood-brain barrier (BBB) is a key factor for central nervous system (CNS) drug development. Although many models for BBB permeability prediction have been developed, they have insufficient accuracy… read more here.
Keywords: blood brain; bbb permeability; brain barrier; prediction ... See more keywords
The Evolving Concept of the Blood Brain Barrier (BBB): From a Single Static Barrier to a Heterogeneous and Dynamic Relay Center
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00405
Abstract: The blood–brain barrier (BBB) helps maintain a tightly regulated microenvironment for optimal central nervous system (CNS) homeostasis and facilitates communications with the peripheral circulation. The brain endothelial cells, lining the brain’s vasculature, maintain close interactions… read more here.
Keywords: blood brain; bbb; brain barrier; brain ... See more keywords
Growth Hormone (GH) Crosses the Blood–Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911546
Abstract: Several motor, sensory, cognitive, and behavioral dysfunctions are associated with neural lesions occurring after a hypoxic injury (HI) in preterm infants. Growth hormone (GH) expression is upregulated in several brain areas when exposed to HI… read more here.
Keywords: blood brain; barrier bbb; brain barrier; brain ... See more keywords