Inhibition of interleukin‐6 trans‐signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.09.009
Abstract: ABSTRACT Vascular inflammation plays a critical role in the pathogenesis of diabetic retinopathy. Recently, Interleukin‐6 (IL‐6) trans‐signaling via soluble IL‐6 receptor (sIL‐6R) has emerged as a prominent regulator of inflammation in endothelial cells. This study… read more here.
Keywords: inflammation; trans signaling; barrier disruption; endothelial cells ... See more keywords
Keratinocyte growth factor ameliorates mycophenolate mofetil-induced intestinal barrier disruption in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.04.012
Abstract: OBJECTIVES Although mycophenolate mofetil-induced (MMF) effectively improves long-term graft survival, the gastrointestinal (GI) side effects due to MMF-induced GI barrier damage limit its use in clinic. Keratinocyte growth factor (KGF) plays a crucial role in… read more here.
Keywords: disruption; induced intestinal; group; barrier disruption ... See more keywords
In Vitro Modeling of Skin Barrier Disruption and its Recovery by Ceramide-Based Formulations.
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-02154-z
Abstract: Disrupted skin barrier, one of the severe attributes of inflammatory skin diseases, is caused by lower content and pathological changes of lipids in the uppermost skin layer-stratum corneum (SC). Restoring skin barrier with native skin… read more here.
Keywords: vitro models; barrier disruption; skin barrier; barrier ... See more keywords
Gut Microbiota From Sjögren syndrome Patients Causes Decreased T Regulatory Cells in the Lymphoid Organs and Desiccation-Induced Corneal Barrier Disruption in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.852918
Abstract: Sjögren syndrome (SS) is an autoimmune inflammatory disorder characterized by secretory dysfunction in the eye and mouth; in the eye, this results in tear film instability, reduced tear production, and corneal barrier disruption. A growing… read more here.
Keywords: intestinal microbiota; gren syndrome; corneal barrier; mice ... See more keywords
Blood–Brain Barrier Disruption (BBBD)-Based Immunochemotherapy for Primary Central Nervous System Lymphoma (PCNSL), Early Results of a Phase II Study
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15041341
Abstract: Simple Summary We present the results of a prospective trial of systemic chemoimmunotherapy for primary CNS lymphoma including the intra-arterial administration of methotrexate and carboplatin with blood–brain barrier disruption. The safety, response rates, and survival… read more here.
Keywords: blood brain; barrier disruption; brain barrier; brain ... See more keywords
Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice
Sign Up to like & getrecommendations! Published in 2023 at "Toxins"
DOI: 10.3390/toxins15040262
Abstract: Microcystin-LR (MC-LR) is an extremely poisonous cyanotoxin that poses a threat to ecosystems and human health. MC-LR has been reported as an enterotoxin. The objective of this study was to determine the effect and the… read more here.
Keywords: hfd treatment; raf erk; group; erk ... See more keywords
Multiple regression analysis of a comprehensive transcriptomic data assembly elucidates mechanically- and biochemically-driven responses to focused ultrasound blood-brain barrier disruption
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.65064
Abstract: Background: Focused ultrasound (FUS) blood brain barrier disruption (BBBD) permits the noninvasive, targeted, and repeatable delivery of drugs to the brain. FUS BBBD also elicits secondary responses capable of augmenting immunotherapies, clearing amyloid-β and hyperphosphorylated… read more here.
Keywords: focused ultrasound; blood brain; bbbd; barrier disruption ... See more keywords