Activated microglia promote invasion and barrier dysfunction of brain endothelial cells via regulating the CXCL13/CXCR5 axis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11832
Abstract: The blood brain barrier (BBB) is a protective border that prevents noxious substances from gaining access to the central nervous system (CNS). CXCL13 is a chemokine from the CXC chemokine family, which has been shown… read more here.
Keywords: barrier dysfunction; invasion barrier; cxcr5; bend cells ... See more keywords
FABP4 induces asthmatic airway epithelial barrier dysfunction via ROS-activated FoxM1.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.106
Abstract: Functional abnormal airway epithelial cells, along with activated inflammatory cells, resulting in chronic airway inflammation, are considered as the characteristic of asthma. Fatty Acid Binding Protein 4 (FABP4) takes part in glucose and lipid homeostasis,… read more here.
Keywords: barrier; barrier dysfunction; airway inflammation; airway epithelial ... See more keywords
1,25-Dihydroxyvitamin D3 targeting VEGF pathway alleviates house dust mite (HDM)-induced airway epithelial barrier dysfunction.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2016.11.004
Abstract: BACKGROUND In our previous studies, we have indentified that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) can alleviate toluene diisocyanate-induced airway epithelial barrier disruption and we also found that vascular endothelial growth factor (VEGF) derived from airway epithelials cells… read more here.
Keywords: barrier; barrier dysfunction; airway epithelial; induced airway ... See more keywords
LPS induces pulmonary microvascular endothelial cell barrier dysfunction by upregulating ceramide production.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2022.110250
Abstract: The specific role of ceramides in pulmonary microvascular endothelial cell (PMVEC) barrier dysfunction remains unclear. In the present study, pretreatment with pan-caspase inhibitors significantly reduced LPS-induced PMVEC apoptosis and helped to stimulate PMVEC barrier reconstruction… read more here.
Keywords: dysfunction; pulmonary microvascular; apoptosis; barrier dysfunction ... See more keywords
Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.11.001
Abstract: Age-associated decay of intercellular interactions impairs the cells' capacity to tightly associate within tissues and form a functional barrier. This barrier dysfunction compromises organ physiology and contributes to systemic failure. The actin cytoskeleton represents a… read more here.
Keywords: barrier; barrier dysfunction; intestinal barrier; age ... See more keywords
Anti‐IL‐12/IL‐23p40 antibody ameliorates dermatitis and skin barrier dysfunction in mice with imiquimod‐induced psoriasis‐like dermatitis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.018
Abstract: ABSTRACT Psoriasis is a chronic inflammatory skin disease characterized by erythema, skin hyperplasia, scales, and keratinocyte hyperproliferation. While the cause of psoriasis is not clearly understood, a dysregulated immune system, especially activation of IL‐23/IL‐17 axis,… read more here.
Keywords: dysfunction mice; barrier dysfunction; psoriasis; dermatitis ... See more keywords
Basal Instinct: Persistence of Barrier Dysfunction.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.09.022
Abstract: In a recent issue of Nature, Ordovas-Montanes et al. (2018) used cutting-edge genomic, epigenetic, and interventional techniques to characterize the cellular ecosystem in allergic chronic rhinosinusitis. They showed that basal epithelial cells "remember" type 2 inflammatory… read more here.
Keywords: persistence barrier; instinct persistence; barrier dysfunction; basal instinct ... See more keywords
Effects of skin moisturizer on the skin barrier dysfunction model: An evaluation of the heel via tape-stripping in healthy, young adults.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of tissue viability"
DOI: 10.1016/j.jtv.2021.02.002
Abstract: BACKGROUND This study seeks to establish the skin barrier dysfunction model at the heel via tape-stripping (TS) by evaluating the skin moisturizing effects. MATERIALS AND METHODS Nineteen young, female participated in the study. A sequence… read more here.
Keywords: barrier dysfunction; dysfunction model; heel; skin barrier ... See more keywords
Nontoxic concentrations of OTA aggravate DON-induced intestinal barrier dysfunction in IPEC-J2 cells via activation of NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.04.021
Abstract: Deoxynivalenol (DON) is well-known enteropathogenic mycotoxin which can alter intestinal barrier functions. Consistently, Ochratoxin A (OTA) ingestion has been found to induce intestinal injuries, including inflammation and diarrhea. However, little is known whether OTA aggravates… read more here.
Keywords: barrier; barrier dysfunction; intestinal barrier; induced intestinal ... See more keywords
Low Dose of Deoxynivalenol Aggravates Intestinal Inflammation and Barrier Dysfunction Induced by Enterotoxigenic Escherichia coli Infection through Activating Macroautophagy/NLRP3 Inflammasomes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07834
Abstract: The toxicity of deoxynivalenol (DON) in healthy humans and animals has been extensively studied. However, whether the natural-low-dose DON is scatheless under unhealthy conditions, especially intestinal injury, is unknown. Infection of enterotoxigenic Escherichia coli (ETEC)… read more here.
Keywords: barrier dysfunction; intestinal inflammation; infection; low dose ... See more keywords
Aflatoxin B1 Induces Intestinal Barrier Dysfunction by Regulating the FXR-Mediated MLCK Signaling Pathway in Mice and in IPEC-J2 Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06931
Abstract: Aflatoxin B1 (AFB1) is a widespread mycotoxin in food and feed. Although the liver is the main target organ of AFB1, the intestine is the first exposure organ to AFB1. However, the mechanism by which… read more here.
Keywords: barrier dysfunction; afb1; intestinal barrier; fxr mediated ... See more keywords