Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease
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DOI: 10.1136/gutjnl-2021-326534
Abstract: Objective Intestinal barrier loss is a Crohn’s disease (CD) risk factor. This may be related to increased expression and enzymatic activation of myosin light chain kinase 1 (MLCK1), which increases intestinal paracellular permeability and correlates… read more here.
Keywords: disease; barrier loss; mlck1; fkbp8 ... See more keywords
High FODMAP diet causes barrier loss via lipopolysaccharide mediated mast cell activation.
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DOI: 10.1172/jci.insight.146529
Abstract: A diet high in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) (HFM) induces gastrointestinal symptoms in patients with irritable bowel syndrome (IBS) and a diet low in FODMAPs (LFM) improves symptoms in up to 60%… read more here.
Keywords: cell activation; barrier loss; cell; mast cell ... See more keywords