Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
Sign Up to like & getrecommendations! Published in 2022 at "Neuron"
DOI: 10.1016/j.neuron.2021.12.029
Abstract: Neurons depend on autophagy to maintain cellular homeostasis, and defects in autophagy are pathological hallmarks of neurodegenerative disease. To probe the role of basal autophagy in the maintenance of neuronal health, we isolated autophagic vesicles… read more here.
Keywords: basal autophagy; nucleoid enriched; engulfment nucleoid; enriched mitochondrial ... See more keywords
Sequential conversion of PtdIns3P to PtdIns(3,5)P2 via endosome maturation couples nutrient signaling to lysosome reformation and basal autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2124499
Abstract: ABSTRACT Macroautophagy/autophagy occurs basally under nutrient-rich conditions in most mammalian cells, contributing to protein and organelle quality control, and protection against aging and neurodegeneration. During autophagy, lysosomes are heavily utilized via their fusion with autophagosomes… read more here.
Keywords: ptdins3p; lysosome reformation; basal autophagy; kinase ... See more keywords
Abstract 4469: Disruption of ATG9A-dependent basal autophagy sensitizes cancer cells to innate inflammatory signaling
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4469
Abstract: Pathogen-derived nucleic acids are recognized by pattern recognition receptors (PRRs), including cGAS and RIG-I, which trigger the innate immune response by activating IRF3-mediated interferon gene expression. In tumors, high levels of chromosomal instability can also… read more here.
Keywords: disruption atg9a; inflammatory signaling; atg9a dependent; basal autophagy ... See more keywords
Basal Autophagy Is Altered in Lagotto Romagnolo Dogs with an ATG4D Mutation
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary Pathology"
DOI: 10.1177/0300985817712793
Abstract: A missense variant in the autophagy-related ATG4D-gene has been associated with a progressive degenerative neurological disease in Lagotto Romagnolo (LR) dogs. In addition to neural lesions, affected dogs show an extraneural histopathological phenotype characterized by… read more here.
Keywords: microscopy; basal autophagy; romagnolo dogs; lagotto romagnolo ... See more keywords
Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.573127
Abstract: The calcium-permeable cation channel TRPM8 (transient receptor potential melastatin 8) is a member of the TRP superfamily of cation channels that is upregulated in various types of cancer with high levels of autophagy, including prostate,… read more here.
Keywords: breast; basal autophagy; cancer cells; cancer ... See more keywords
MitoSNARE Assembly and Disassembly Factors Regulate Basal Autophagy and Aging in C. elegans
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044230
Abstract: SNARE proteins reside between opposing membranes and facilitate vesicle fusion, a physiological process ubiquitously required for secretion, endocytosis and autophagy. With age, neurosecretory SNARE activity drops and is pertinent to age-associated neurological disorders. Despite the… read more here.
Keywords: snare; disassembly factors; mitosnare assembly; basal autophagy ... See more keywords