Biobanked tracheal basal cells retain the capacity to differentiate
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.925
Abstract: While airway epithelial biorepositories have established roles in the study of bronchial progenitor stem (basal) cells, the utility of a bank of tracheal basal cells from pediatric patients, who have or are suspected of having… read more here.
Keywords: basal cells; retain capacity; tracheal basal; biobanked tracheal ... See more keywords
Expression and localization of endogenous phospholipase Cβ3 confined to basal cells in situ of immature ducts and adult excretory ducts of submandibular gland of mice.
Sign Up to like & getrecommendations! Published in 2019 at "Acta histochemica"
DOI: 10.1016/j.acthis.2019.151497
Abstract: Our previous study demonstrated that, different from the parotid and sublingual glands, the submandibular glands of adult mice did not show an immunoblot band for PLCβ3 which is critical in the secretion mechanism by muscarinic… read more here.
Keywords: expression; basal cells; adult excretory; excretory ducts ... See more keywords
Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.11.010
Abstract: Summary DACH1 abundance is reduced in human malignancies, including breast cancer. Herein DACH1 was detected among multipotent fetal mammary stem cells in the embryo, among mixed lineage precursors, and in adult basal cells and (ERα+)… read more here.
Keywords: dachshund depletion; ductal branching; depletion disrupts; mammary gland ... See more keywords
Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03414-6
Abstract: The epidermis is a multi-layered epithelium that serves as a barrier against water loss and environmental insults. Its morphogenesis occurs through a tightly regulated program of biochemical and architectural changes during which basal cells commit… read more here.
Keywords: delamination; tctex; basal cells; cadherin ... See more keywords
Basal epithelial cells in prostate development, tumorigenesis, and cancer progression
Sign Up to like & getrecommendations! Published in 2023 at "Cell Cycle"
DOI: 10.1080/15384101.2023.2206502
Abstract: ABSTRACT The prostate epithelium is composed of two predominant cell populations: luminal and basal epithelial cells. Luminal cells have a secretory function that supports male fertility while basal cells function in regeneration and maintenance of… read more here.
Keywords: basal cells; development; basal; basal epithelial ... See more keywords
Transduction of surface and basal cells in Rhesus macaque lung following repeat dosing with AAV1CFTR.
Sign Up to like & getrecommendations! Published in 2020 at "Human gene therapy"
DOI: 10.1089/hum.2020.207
Abstract: To test the effectiveness of repeat dosing, we sprayed two doses (1013 vg each) of AAV1Δ27-264-CFTR into airways of four Rhesus monkeys at 0 and 30 days, followed by a single dose of 1013 vg… read more here.
Keywords: surface; basal cells; repeat dosing; lung ... See more keywords
rAAV-MEDIATED EDITING OF THE G551D CFTR MUTATION IN FERRET AIRWAY BASAL CELLS.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2022.036
Abstract: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), a chronic disease that affects multiple organs including the lung. We developed a CF ferret model of a scarless G551→D substitution… read more here.
Keywords: basal cells; cftr; gene editing; airway basal ... See more keywords
Bronchiolar adenoma with squamous metaplasia: a distinct phenotype.
Sign Up to like & getrecommendations! Published in 2023 at "Histopathology"
DOI: 10.1111/his.14907
Abstract: AIMS Pulmonary bronchiolar adenoma is a benign lung tumour characterised by nodular proliferation of bilayered bronchiolar-type epithelium with a continuous layer of basal cells. The aim of this study was to describe a distinct and… read more here.
Keywords: pulmonary bronchiolar; adenoma squamous; basal cells; squamous metaplasia ... See more keywords
Abstract PR009: Basal cell lineage plasticity in prostate homeostasis, repair and tumor initiation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-pr009
Abstract: Androgen deprivation is the paradigm of prostate cancer treatment. It is often linked to the loss of luminal cells, but the basal cell fates under androgen deprivation, prostatitis and cancer initiation remain unclear. Using a… read more here.
Keywords: cell; basal cells; basal; cell lineage ... See more keywords
The Kinome of Human Alveolar Type II and Basal Cells, and its Reprogramming in Lung Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2018-0283oc
Abstract: The discovery of mutant tyrosine kinases as oncogenic drivers of lung adenocarcinomas has changed our basic understanding of the development and therapy of lung cancer. Yet, we have an incomplete understanding of the expressed kinases… read more here.
Keywords: basal cells; lung cancer; lung; alveolar type ... See more keywords
Basal Cell-derived WNT7A Promotes Fibrogenesis at the Fibrotic Niche in Idiopathic Pulmonary Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0074oc
Abstract: Loss of epithelial integrity, bronchiolarization, and fibroblast activation are key characteristics of idiopathic pulmonary fibrosis (IPF). Prolonged accumulation of basal-like cells in IPF may impact the fibrotic niche to promote fibrogenesis. To investigate their role… read more here.
Keywords: cell; basal cells; basal; fibrotic niche ... See more keywords