Antisense oligonucleotides targeting basal forebrain ATXN2 enhances spatial memory and ameliorates sleep deprivation-induced fear memory impairment in mice.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3013
Abstract: INTRODUCTION Regulation of brain-derived neurotrophic factor (BDNF) in the basal forebrain ameliorates sleep deprivation-induced fear memory impairments in rodents. Antisense oligonucleotides (ASOs) targeting ATXN2 was a potential therapy for spinocerebellar ataxia, whose pathogenic mechanism associates… read more here.
Keywords: deprivation induced; sleep deprivation; fear memory; memory ... See more keywords
Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22700
Abstract: Down syndrome (DS), trisomy 21, is marked by intellectual disability and a premature aging profile including degeneration of the basal forebrain cholinergic neuron (BFCN) projection system, similar to Alzheimer's disease (AD). Although data indicate that… read more here.
Keywords: cholinergic neuron; choline; choline supplementation; maternal choline ... See more keywords
Altered basal forebrain BOLD signal variability at rest in posttraumatic stress disorder: A potential candidate vulnerability mechanism for neurodegeneration in PTSD
Sign Up to like & getrecommendations! Published in 2021 at "Human Brain Mapping"
DOI: 10.1002/hbm.25454
Abstract: Individuals with posttraumatic stress disorder (PTSD) are at increased risk for the development of various forms of dementia. Nevertheless, the neuropathological link between PTSD and neurodegeneration remains unclear. Degeneration of the human basal forebrain constitutes… read more here.
Keywords: seed; neurodegeneration; bold signal; basal forebrain ... See more keywords
Retrograde Axonal Transport of Neurotrophins in Basal Forebrain Cholinergic Neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1990-2_13
Abstract: Axonal transport is key for the survival and function of all neurons. This process is especially important in basal forebrain cholinergic neurons due to their extremely long and diffuse axonal projections. These neurons are critical… read more here.
Keywords: transport; axonal transport; biology; cholinergic neurons ... See more keywords
Longitudinal Alzheimer's Degeneration Reflects the Spatial Topography of Cholinergic Basal Forebrain Projections.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.001
Abstract: The cholinergic neurons of the basal forebrain (BF) provide virtually all of the brain's cortical and amygdalar cholinergic input. They are particularly vulnerable to neuropathology in early Alzheimer's disease (AD) and may trigger the emergence… read more here.
Keywords: topography; basal forebrain; cortico amygdalar; degeneration ... See more keywords
Corrigendum to ‘The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom?’ [Curr Opin Neurobiol 2017, 44:159–166]
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.07.007
Abstract: www.sciencedirect.com Figure 1 was adapted with permission from Figures previously published in ‘The mouse brain in stereotaxic coordinates’ (ISBN: 9780123910578)by George Paxinos & Keith Franklin (2008) 3rd ed. New York, Academic Press (Copyright Elsevier). In… read more here.
Keywords: many neural; neural species; menagerie basal; basal forebrain ... See more keywords
Basal forebrain septal nuclei are enlarged in healthy subjects prior to the development of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.01.014
Abstract: Alzheimer's disease (AD) is known to be associated with loss of cholinergic neurons in the nucleus basalis of Meynert, located in the posterior basal forebrain. Structural changes of septal nuclei, located in the anterior basal… read more here.
Keywords: septal nuclei; alzheimer disease; basal forebrain; forebrain septal ... See more keywords
Quantitative EEG and cholinergic basal forebrain atrophy in Parkinson's disease and mild cognitive impairment
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2021.05.023
Abstract: Cholinergic degeneration is a key feature of dementia in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD). Quantitative electro-encephalography (EEG) metrics are altered in both conditions from early stages, and recent research in… read more here.
Keywords: eeg; disease; basal forebrain; parkinson disease ... See more keywords
Segregation of the human basal forebrain using resting state functional MRI
Sign Up to like & getrecommendations! Published in 2018 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2018.02.042
Abstract: &NA; The basal forebrain (BF) is poised to play an important neuromodulatory role in brain regions important to cognition due to its broad projections and complex neurochemistry. While significant in vivo work has been done… read more here.
Keywords: basal; state functional; basal forebrain; resting state ... See more keywords
A glutamatergic basal forebrain to midbrain circuit mediates wakefulness and defensive behavior
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.108979
Abstract: Defensive behavior, a group of responses that evolved due to threatening stimuli, is crucial for animal survival in the natural environment. For defensive measures to be timely and successful, a high arousal state and immediate… read more here.
Keywords: defensive behavior; wakefulness defensive; glutamatergic; basal forebrain ... See more keywords
Increase in cortical endocannabinoid signaling in a rat model of basal forebrain cholinergic dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.08.008
Abstract: The basal forebrain cholinergic pathways progressively degenerate during the progression of Alzheimer's disease, leading to an irreversible impairment of memory and thinking skills. The stereotaxic lesion with 192IgG-saporin in the rat brain has been used… read more here.
Keywords: basal; ecb; basal forebrain; forebrain cholinergic ... See more keywords