Hypoglycemia After Initiation of Basal Insulin in Patients with Type 2 Diabetes in the United States: Implications for Treatment Discontinuation and Healthcare Costs and Utilization
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DOI: 10.1007/s12325-017-0592-x
Abstract: IntroductionHypoglycemia and fear of hypoglycemia may contribute to basal insulin discontinuation, poor glycemic control, and increased healthcare burden in patients with type 2 diabetes (T2D). This study aimed to determine the impact of hypoglycemia soon… read more here.
Keywords: basal insulin; hypoglycemia; discontinuation; initiation ... See more keywords
Safety and Efficacy of High Versus Standard Starting Doses of Insulin Glargine in Overweight and Obese Chinese Individuals with Type 2 Diabetes Mellitus Inadequately Controlled on Oral Antidiabetic Medications (Beyond VII): Study Protocol for a Randomized Controlled Trial
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DOI: 10.1007/s12325-018-0717-x
Abstract: BackgroundTreatment with basal insulin in Chinese populations is currently sub-optimal, with delayed initiation of insulin treatment and inadequate dose titration. Increasing the initial dose of insulin may be a practicable and effective solution to the… read more here.
Keywords: insulin; overweight obese; safety; study ... See more keywords
Bridging the Gap Between Self-Reported and Claims-Derived Adherence Measures for Basal Insulin Among Patients with Type 2 Diabetes Mellitus
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DOI: 10.1007/s12325-018-0828-4
Abstract: IntroductionComplex or personalized insulin regimens challenge traditional adherence measures. Our objective was to develop an improved basal insulin (BI) adherence measure using both patient-reported and administrative claims data, resulting in a more complete measure.MethodsPatients’ self-reported… read more here.
Keywords: insulin; claims based; based mpr; basal insulin ... See more keywords
Optimizing Glycemic Control Through Titration of Insulin Glargine 100 U/mL: A Review of Current and Future Approaches with a Focus on Asian Populations
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DOI: 10.1007/s13300-017-0322-z
Abstract: Various data have demonstrated inadequate glycemic control amongst Asians with type 2 diabetes mellitus (T2DM), possibly on account of suboptimal titration of basal insulin—an issue which needs to be further examined. Here we review the… read more here.
Keywords: insulin; titration; asian populations; titration basal ... See more keywords
Glucose Control and Weight Change Associated with Treatment with Exenatide Compared with Basal Insulin: A Retrospective Study
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DOI: 10.1007/s13300-017-0359-z
Abstract: IntroductionThe aim of the study was to compare glycemic and weight change outcomes for type 2 diabetes patients treated with either exenatide once-weekly (EQW) or exenatide twice-daily (EBID) with those patients treated with basal insulin… read more here.
Keywords: basal insulin; change; weight change; mmol mol ... See more keywords
Diabetes Management and Healthcare Resource Use When Intensifying from Basal Insulin to Basal-Bolus: A Survey of Type 2 Diabetes Patients
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DOI: 10.1007/s13300-018-0487-0
Abstract: IntroductionCurrently, there is limited knowledge about the experiences and challenges type 2 diabetes (T2D) patients face when intensifying from basal insulin to more complex regimens. The purpose of this study was to examine the experiences… read more here.
Keywords: healthcare resource; basal; resource use; basal bolus ... See more keywords
Safety and Efficacy of DPP4 Inhibitor and Basal Insulin in Type 2 Diabetes: An Updated Review and Challenging Clinical Scenarios
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DOI: 10.1007/s13300-018-0488-z
Abstract: The safety and efficacy of dipeptidyl peptidase-4 (DPP4) inhibitors as monotherapy or in combination with other oral antidiabetic agents or basal insulin are well established. DPP4 inhibitors stimulate glucose-dependent insulin secretion and inhibit glucagon production.… read more here.
Keywords: insulin; dpp4 inhibitors; safety efficacy; type diabetes ... See more keywords
Treating Patients with Type 2 Diabetes Mellitus Uncontrolled on Basal Insulin in the Czech Republic: Cost-Effectiveness of IDegLira Versus iGlarLixi
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DOI: 10.1007/s13300-019-0569-7
Abstract: IntroductionFew patients with type 2 diabetes mellitus (T2DM) achieve recommended glycemic control targets in the Czech Republic. Novel therapies, such as fixed-ratio combinations of basal insulin plus glucagon-like peptide-1 receptor agonists, may contribute to better… read more here.
Keywords: insulin; cost effectiveness; czech republic; versus iglarlixi ... See more keywords
Clinical Outcomes of Switching to Insulin Glargine 300 U/ml from Other Basal Insulins in People with Type 2 Diabetes in Italy: A Real-World Study
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DOI: 10.1007/s13300-020-00902-1
Abstract: Primary aim was to provide real-world evidence of the outcomes after the switch to glargine 300 U/ml (Gla-300) from other basal insulins (first or second generation) in Italy. Multicenter, observational, retrospective study based on electronic… read more here.
Keywords: gla 300; real world; insulin; basal ... See more keywords
Delphi-Based Consensus on Treatment Intensification in Type 2 Diabetes Subjects Failing Basal Insulin Supported Oral Treatment: Focus on Basal Insulin + GLP-1 Receptor Agonist Combination Therapies
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DOI: 10.1007/s13300-021-01012-2
Abstract: The aim of this study was to elaborate a consensus on treatment intensification strategies in patients with type 2 diabetes failing basal insulin supported oral therapy (BOT). The panel focused on glucagon-like peptide-1 receptor agonists… read more here.
Keywords: insulin; glp 1ra; bot; treatment ... See more keywords
Once-Daily Oral Semaglutide Versus Injectable GLP-1 RAs in People with Type 2 Diabetes Inadequately Controlled on Basal Insulin: Systematic Review and Network Meta-analysis
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DOI: 10.1007/s13300-021-01034-w
Abstract: The relative efficacy and safety of once-daily oral semaglutide vs. injectable glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in subjects with type 2 diabetes (T2D) inadequately controlled on basal insulin were assessed using network meta-analysis (NMA).… read more here.
Keywords: semaglutide; glp ras; basal insulin; oral semaglutide ... See more keywords