Oscillating calcium signals in smooth muscle cells underlie the persistent basal tone of internal anal sphincter
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DOI: 10.1002/jcp.30279
Abstract: A persistent basal tone in the internal anal sphincter (IAS) is essential for keeping the anal canal closed and fecal continence; its inhibition via the rectoanal inhibitory reflex (RAIR) is required for successful defecation. However,… read more here.
Keywords: persistent basal; basal tone; tone; tone internal ... See more keywords
TMEM16A in smooth muscle cells acts as a pacemaker channel in the internal anal sphincter
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DOI: 10.1038/s42003-024-05850-1
Abstract: Maintenance of fecal continence requires a continuous or basal tone of the internal anal sphincter (IAS). Paradoxically, the basal tone results largely from high-frequency rhythmic contractions of the IAS smooth muscle. However, the cellular and… read more here.
Keywords: muscle; basal tone; internal anal; smooth muscle ... See more keywords