Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease
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DOI: 10.1007/s00044-020-02666-6
Abstract: A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted… read more here.
Keywords: alzheimer disease; base derivatives; agents treatment; treatment alzheimer ... See more keywords
2-(3-Hydroxybenzyl)benzo[d]isothiazol-3(2H)-one Mannich base derivatives as potential multifunctional anti-Alzheimer’s agents
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DOI: 10.1007/s00044-021-02725-6
Abstract: A series of 2-(3-hydroxybenzyl)benzo[d]isothiazol-3(2H)-one Mannich base derivatives were designed as potential multifunctional agents against Alzheimer’s disease. The twelve derivatives were synthesized and evaluated with various biological activities. In vitro, biological assays showed that most of… read more here.
Keywords: benzo isothiazol; mannich base; base derivatives; hydroxybenzyl benzo ... See more keywords
Biologically Active Water Soluble Novel Biopolymer/Hydrazide Based O-Carboxymethyl Chitosan Schiff Bases: Synthesis and Characterisation
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DOI: 10.1007/s10904-020-01487-9
Abstract: Six new N,N,O tridentate water soluble hydrazide based O-carboxymethyl chitosan Schiff base derivatives have been prepared through in-situ synthesis. The degree of substitution of schiff base derivatives was calculated theoretically and the derivatives were prepared… read more here.
Keywords: schiff; carboxymethyl chitosan; chitosan schiff; base derivatives ... See more keywords
DFT and Electrochemical Investigations on the Corrosion Inhibition of Mild Steel by Novel Schiff’s Base Derivatives in 1 M HCl Solution
Sign Up to like & getrecommendations! Published in 2021 at "Arabian Journal for Science and Engineering"
DOI: 10.1007/s13369-020-05229-4
Abstract: This study aims to explore the inhibitory action of certain derivatives of Schiff’s base, namely 4-(pyridin-2-ylimino) pentan-2-one (CE5),4-(pyrimidin-2-ylimino) pentan-2-one (CE4) and 4-((1H-tetrazol-5-yl) imino) pentan-2-one (CE20) against mild steel (MS) corrosion in 1 M HCl by the… read more here.
Keywords: mild steel; base derivatives; corrosion; base ... See more keywords
Two-photon absorption property and excellent optical limiting response of three Schiff base derivatives with large conjugated system
Sign Up to like & getrecommendations! Published in 2019 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2018.07.046
Abstract: Abstract In this work, three Schiff base derivatives with large conjugated system have been elaborately designed and synthesized, in which bithienyl (1), pyrenyl (2) and anthryl (3) connect an azo moiety (N=N) monomer through conjugation… read more here.
Keywords: two photon; base derivatives; three schiff; schiff base ... See more keywords
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.12.009
Abstract: A series of aurone Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated that most of the derivatives were selective AChE inhibitors with good… read more here.
Keywords: mannich base; alzheimer disease; aurone mannich; base derivatives ... See more keywords
High anticancer potency on tumor cells of dehydroabietylamine Schiff-base derivatives and a copper(II) complex.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.041
Abstract: Five bioactive dehydroabietylamine Schiff-base derivatives (L1-L5) had been synthesized from Dehydroabietylamine (L0), and the complex Cu(L1)2 had been obtained from the compound L1 and copper(II) acetate. Their activities against Hela (cervix), MCF-7 (breast), A549 (lung),… read more here.
Keywords: ic50 value; base derivatives; dehydroabietylamine schiff; cell ... See more keywords
Structural, SC-XRD and spectroscopic investigation of schiff base derivatives: A joint experimental and DFT investigation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.04.084
Abstract: Abstract In this study, three Schiff base derivatives of 1,3-bis[(E)-(4-dimethylaminobenzylidene)amino] propan-2-ol (BDP), 1,3-bis[(E)-(4-methoxybenzylidene)amino] propan-2-ol (BMP) and 1,3-Bis[(E)-(4-chlorobenzylidene)amino] propan-2-ol (BCP) were synthesized and resolved into their single crystal structures. Interestingly, the crystal structures of compound BDP… read more here.
Keywords: investigation; hydrogen bonds; base derivatives; schiff base ... See more keywords
Synthesis, antimicrobial and antioxidant evaluation with in silico studies of new thiazole Schiff base derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131465
Abstract: Abstract A series of nineteen thiazole Schiff base derivatives 2a-2s were synthesized (Scheme 1) and elucidated by spectral analyses (IR, 1H NMR and HRMS). The evaluation of their antimicrobial activities against two gram-positive, two gram-negative,… read more here.
Keywords: base derivatives; compounds displayed; thiazole schiff; schiff base ... See more keywords
Zinc(II) mononuclear complexes with Schiff base derivatives of 2-aminofluorene. Synthesis, structural characterization, and optical properties
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Coordination Chemistry"
DOI: 10.1080/00958972.2020.1830977
Abstract: Abstract Three Schiff base ligands derived from 2-aminofluorene and 3-methoxysalicylaldehyde (HL1), 3-ethoxysalicylaldehyde (HL2), or 2-formyl-6-hydroxymethyl-p-cresol (HL3) were synthesized and structurally characterized by X-ray diffraction on single crystals. The mononuclear complexes [Zn(L1)2] (4), [Zn(L2)2] (5), [Zn(L3)2]·CHCl3… read more here.
Keywords: mononuclear complexes; zinc mononuclear; base derivatives; complexes schiff ... See more keywords
Synthesis and Characterization of Disulfide-Schiff Base Derivatives and in vitro Investigation of Their Antibacterial Activity Against Multidrug-Resistant Acinetobacter baumannii Isolates: A New Study
Sign Up to like & getrecommendations! Published in 2018 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363218020184
Abstract: In this study two different methods without a catalyst and with a CeO2 nano catalyst were used for the synthesis of dimeric disulfide-Schiff bases. The dimeric disulfide-Schiff base derivatives were characterized by FT-IR, NMR, and… read more here.
Keywords: antibacterial activity; base derivatives; disulfide schiff; acinetobacter baumannii ... See more keywords