Potassium-Base-Mediated Autoxidative Diastereoselective Homocoupling of N-Acyl-2-aminoacetophenones.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00618
Abstract: We herein report a general and highly efficient method for the synthesis of dl-2,3-diamide-1,4-diones via autoxidative dehydrogenative homocoupling of N-acyl-2-aminoacetophenones mediated by t-BuOK. The transformation is mild, operationally simple, and environmentally friendly. Control experiments and… read more here.
Keywords: potassium base; base mediated; acyl aminoacetophenones; homocoupling acyl ... See more keywords
Brønsted Base Mediated Stereoselective Diphosphination of Terminal Alkynes with Diphosphanes.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01209
Abstract: A Brønsted base mediated stereoselective diphosphination of terminal alkynes with diphosphanes proceeds to deliver the corresponding (E)-1,2-diphosphinoethenes in good yields. The reaction of aromatic alkynes occurs efficiently in the presence of a catalytic amount of… read more here.
Keywords: base mediated; mediated stereoselective; diphosphination terminal; nsted base ... See more keywords
Base-Mediated Meerwein-Ponndorf-Verley Reduction of Aromatic and Heterocyclic Ketones.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02342
Abstract: An experimental protocol to achieve the Meerwein-Ponndorf-Verley (MPV) reduction of ketones under mildly basic conditions is reported. The transformation is tolerant of a range of ketone substrates, including O- and S-containing heterocycles, is scalable, and… read more here.
Keywords: base mediated; reduction; meerwein ponndorf; ponndorf verley ... See more keywords
Base-Mediated Coupling Reactions of Benzenesulfonyl Azides with Proline: Synthesis of Proline-Derived Benzenesulfonamides
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DOI: 10.1021/acsomega.1c05331
Abstract: Sulfonamides and lipids are widely found in natural products, bioactive substances, and pharmaceuticals. Here, we report N-sulfonylation and esterification of carboxylic acids in an environment-friendly one-pot tandem protocol involving 1,2-dichloroethane (DCE). Moreover, 1,8-diazabicyclo (5.4.0) undec-7-ene… read more here.
Keywords: mediated coupling; coupling reactions; reactions benzenesulfonyl; base ... See more keywords
Base-Mediated Deuteration of Organic Molecules: A Mechanistic Insight.
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DOI: 10.1021/acsomega.8b01329
Abstract: A base-promoted, step-economical, and cost-effective strategy for introducing heavy isotopes into the organic molecules has been developed. The schemes involve the selective deuteration of various electronically distinct molecules that are formed because of deuterioamination, deuteriothiolation,… read more here.
Keywords: base mediated; deuteration organic; mediated deuteration; base ... See more keywords
Base mediated spirocyclization of quinazoline: one-step synthesis of spiro-isoindolinone dihydroquinazolinones
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DOI: 10.1039/c9ra09567e
Abstract: A novel approach for the spiro-isoindolinone dihydroquinazolinones has been demonstrated from 2-aminobenzamide and 2-cyanomethyl benzoate in the presence of KHMDS as a base to get moderate yields. The reaction has been screened in various bases… read more here.
Keywords: base mediated; mediated spirocyclization; isoindolinone dihydroquinazolinones; spiro isoindolinone ... See more keywords
Manganese(ii) Schiff-base-mediated reversible deactivation controlled radical polymerization of vinyl acetate
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DOI: 10.1039/d1nj00493j
Abstract: The manganese Schiff-base complexes were applied in the OMRP of vinyl acetate. read more here.
Keywords: base mediated; manganese schiff; schiff base; vinyl acetate ... See more keywords
Chemoselective and one-pot synthesis of novel coumarin-based cyclopenta[c]pyrans via base-mediated reaction of α,β-unsaturated coumarins and β-ketodinitriles
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DOI: 10.1039/d2ra00594h
Abstract: In this paper, the base-mediated cascade reactions of 4-chloro-3-vinyl coumarins with β-ketodinitriles were demonstrated, allowing the efficient synthesis of coumarin-based cyclopenta[c]pyran-7-carbonitriles with interesting chemoselectivity. These transformations include the domino-style formation of C–C/C–C/C–O bonds through a… read more here.
Keywords: based cyclopenta; coumarin based; synthesis; coumarins ketodinitriles ... See more keywords
Base-mediated ynone-isocyanide [3+2] cycloaddition: a general method to 2,3,4-tri-substituted 1-H-pyrroles and bis-pyrroles.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01586f
Abstract: A transition-metal-free and base-promoted one-pot synthesis of 2,3,4-trisubstituted 1-H-pyrroles has been developed. The reaction occurs through the [3+2] cycloaddition of differently functionalized ynones and isocyanides. The reaction's advantageous features are operational simplicity, atom economy, and… read more here.
Keywords: ynone isocyanide; isocyanide cycloaddition; mediated ynone; base mediated ... See more keywords