pH dependence of C•A, G•A and A•A mismatches in the stem of precursor microRNA-31.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2022.106763
Abstract: MicroRNAs (miRNAs) are important regulators of post-transcriptional gene expression. Mature miRNAs are generated from longer transcripts (primary, pri- and precursor, pre-miRNAs) through a series of highly coordinated enzymatic processing steps. The sequence and structure of… read more here.
Keywords: mismatches stem; pre; dependence mismatches; base pair ... See more keywords
Taqman Assay for Genotyping CKD-Associated APOL1 SNP rs60910145: A Cautionary Note
Sign Up to like & getrecommendations! Published in 2019 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2018.09.018
Abstract: When combined with results from the rs73885319 and rs71785313 SNP assays, will result in an inferred haplotype not observed on African chromosomes. To the Editor: There are 2 APOL1 variant haplotypes, G1 and G2, that… read more here.
Keywords: taqman; base pair; haplotype; snp ... See more keywords
Synthesis of bio-based cyclic carbonate from vegetable oil methyl ester by CO2 fixation with acid-base pair MOFs
Sign Up to like & getrecommendations! Published in 2020 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2020.112155
Abstract: Abstract Bio-based five-membered cyclic carbonates were synthesized from renewable O-acetyl methyl ricinoleate that from crops and CO2 via two steps and the products after each reaction step were characterized by fourier transform infrared spectroscopy. For… read more here.
Keywords: methyl; acid base; base pair; co2 ... See more keywords
The Base Pairs of Isoguanine and 8-Aza-7-deazaisoguanine with 5-Methylisocytosine as Targets for DNA Functionalization.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00584
Abstract: The isoguanine-isocytosine base pair (isoG-isoC) represents an important expansion of the DNA coding system. The base pair is more stable than the canonical adenine-thymine or guanine-cytosine pairs. However, nothing is known on the functionalization of… read more here.
Keywords: base pair; functionalization; chemistry; aza deazaisoguanine ... See more keywords
Principles of tRNAAla Selection by Alanyl–tRNA Synthetase Based on the Critical G3·U70 Base Pair
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b01827
Abstract: Throughout evolution, the presence of a single G3·U70 mismatch in the acceptor stem of tRNAAla is the major determinant for aminoacylation with alanine by alanyl–tRNA synthetase (AlaRS). Recently reported crystal structures of the complexes AlaRS–tRNAAla/G3·U70… read more here.
Keywords: trna synthetase; alanyl trna; trnaala u70; base pair ... See more keywords
Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21840-x
Abstract: NH groups in proteins or nucleic acids are the most challenging target for chemical shift prediction. Here we show that the RNA base pair triplet motif dictates imino chemical shifts in its central base pair.… read more here.
Keywords: chemical shifts; rna; chemical shift; base pair ... See more keywords
Computational and NMR studies of RNA duplexes with an internal pseudouridine-adenosine base pair
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52637-0
Abstract: Pseudouridine (Ψ) is the most common chemical modification present in RNA. In general, Ψ increases the thermodynamic stability of RNA. However, the degree of stabilization depends on the sequence and structural context. To explain experimentally… read more here.
Keywords: pseudouridine; rna duplexes; base pair; duplexes internal ... See more keywords
UV-induced hydrogen transfer in DNA base pairs promoted by dark nπ* states.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc06180k
Abstract: Dark nπ* states were shown to have substantial contribution to the destructive photochemistry of pyrimidine nucleobases. Based on quantum-chemical calculations, we demonstrate that the characteristic hydrogen bonding pattern of the GC base pair could facilitate… read more here.
Keywords: induced hydrogen; dark states; base pair; base ... See more keywords
Reversible regulation of metallo-base-pair interactions for DNA dehybridization by ultrasound.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc02402g
Abstract: Mechanical force applied by ultrasound in solution leads to the dissociation of DNA metallo-base-pair interactions when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length. The annealing and force-induced denaturing process is followed by… read more here.
Keywords: pair interactions; metallo base; base pair;
Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra02831f
Abstract: Ryotaro Notomi, Lei Wang, Shigeki Sasaki* and Yosuke Taniguchi *a We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-20deoxycytosine and 20-deoxyguanosine base pair by triplex DNA formation. Triplex-forming… read more here.
Keywords: dna; nucleoside analogues; base pair; triplex dna ... See more keywords
Selectivity and efficiency in the ligation of the pyrene:abasic base pair by T4 and PBCV-1 DNA ligases.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03079a
Abstract: Remarkable selectivity was observed in the ligation of 5'-phosphate 1-pyrene nucleotide terminated strands across from an abasic lesion in a DNA-templated ligation reaction by two different ligases suggesting that pyrene-terminated strands could be used in… read more here.
Keywords: ligation; base pair; dna; pyrene ... See more keywords