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Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.243
Abstract: Loss-of-function mutations in the BRCA1 and BRCA2 genes increase the risk of cancer. Owing to their function in homologous recombination repair, much research has focused on the unstable genomic phenotype of BRCA1/2 mutant cells manifest…
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Keywords:
mutagenesis;
brca1;
brca1 brca2;
base substitution ... See more keywords
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Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-1943-3
Abstract: Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature 1 . Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium 2 of…
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Keywords:
human cancer;
cancer;
base substitution;
mutational signatures ... See more keywords