Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA
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DOI: 10.1038/s41586-022-04398-6
Abstract: Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions1–5, diffuse hypermutation termed omikli6, and longer strand-coordinated events termed kataegis3,7–9. Here… read more here.
Keywords: cancer; base substitutions; clustered mutations; mutational processes ... See more keywords
Relation between DNA ionization potentials, single base substitutions and pathogenic variants
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DOI: 10.1186/s12864-019-5867-y
Abstract: It is nowadays clear that single base substitutions that occur in the human genome, of which some lead to pathogenic conditions, are non-random and influenced by their flanking nucleobase sequences. However, despite recent progress, the… read more here.
Keywords: ionization potentials; base; base substitutions; single base ... See more keywords