Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidences of Stereospecific Recognition.
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DOI: 10.1021/acs.jmedchem.9b01340
Abstract: We report the identification of two subsets of fluorinated nonxanthine A2B adenosine receptor antagonists. The novel derivatives explore the effect of fluorination at different positions of two pyrimidine-based scaffolds. The most interesting ligands combine excellent… read more here.
Keywords: antagonists optimization; trifluorinated pyrimidine; pyrimidine; based a2b ... See more keywords