Thienopyrimidine‐based agents bearing diphenylurea: Design, synthesis, and evaluation of antiproliferative and antiangiogenic activity
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200349
Abstract: An important role has been considered for the vascular endothelial growth factor receptor 2 (VEGFR‐2) in the angiogenesis process, so that its inhibition is an important scientific way for cancer treatment. In this work, new… read more here.
Keywords: thienopyrimidine based; bearing diphenylurea; activity; sw480 huvec ... See more keywords
Quinazolin-4(3H)-one based agents bearing thiadiazole-urea: Synthesis and evaluation of anti-proliferative and antiangiogenic activity.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104553
Abstract: A series of quinazolin-4(3H)-one based agents containing thiadiazole-urea were designed, synthesized, and biologically evaluated. The proliferation rate of PC3 cells was moderately reduced by compound 9f (IC50 = 17.7 μM)which was comparable with sorafenib (IC50 = 17.3 μM). There… read more here.
Keywords: agents bearing; based agents; one based; quinazolin one ... See more keywords
Molecular MR Imaging with Gd(III)-based Agents: Challenges and Key Advances.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b09149
Abstract: In an era of personalized medicine, the clinical community has become increasingly focused on understanding diseases at the cellular and molecular level. Magnetic resonance imaging (MRI) is a powerful imaging modality for acquiring anatomical and… read more here.
Keywords: based agents; molecular imaging; key advances; iii based ... See more keywords
Effects of the structure of lipid-based agents in their complexation with a single stranded mRNA fragment: a computational study.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d2sm00403h
Abstract: In this work we employed fully atomistic molecular dynamics simulations, aiming towards a better understanding of the mechanisms associated with the formation and the stability of lipid-based RNA nanoassemblies, in an aqueous environment. We examined… read more here.
Keywords: effects structure; complexation; agents complexation; based agents ... See more keywords
Threat potential of pharmaceutical based agents
Sign Up to like & getrecommendations! Published in 2020 at "Intelligence and National Security"
DOI: 10.1080/02684527.2020.1750158
Abstract: ABSTRACT The potential use of ‘pharmaceuticals’ has been identified by civilian law enforcement agencies, and counter-terrorism responders, as a threat that fills the gap between physical restraint and lethal weapons. This rise in availability of… read more here.
Keywords: threat potential; based agents; threat; potential pharmaceutical ... See more keywords
Diverse Possibilities of Si-Based Agent, a Unique New Antioxidant
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12051061
Abstract: Antioxidant therapy is an effective approach for treating diseases in which oxidative stress is involved in the onset of symptoms. This approach aims to rapidly replenish the antioxidant substances in the body when they are… read more here.
Keywords: agent unique; possibilities based; oxidative stress; diverse possibilities ... See more keywords