Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors.
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DOI: 10.1021/acschembio.7b00543
Abstract: The deubiquitinases, or DUBs, are associated with various human diseases, including neurological disorders, cancer, and viral infection, making them excellent candidates for pharmacological intervention. Drug discovery campaigns against DUBs require enzymatic deubiquitination assays amenable for… read more here.
Keywords: small molecule; platform; molecule inhibitors; assay platform ... See more keywords