Synthesis and evaluation of N-heteroaromatic ring-based analogs of piperlongumine as potent anticancer agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.046
Abstract: Piperlongumine (PL) selectively targets a wide spectrum of cancer cells and induces their death by triggering various pathways, including apoptosis, necrosis and autophagy. However, the poor solubility is a serious concern for intensive study and… read more here.
Keywords: heteroaromatic ring; based analogs; potent anticancer; ring ... See more keywords
Design, synthesis, and biological evaluation of novel amide and hydrazide based thioether analogs targeting Histone deacteylase (HDAC) enzymes.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.011
Abstract: Development of HDAC inhibitors have become an ultimate need targeting different types of cancer. In silico virtual screening was applied to screen novel scaffolds via scaffold hopping strategy to develop different acrylamide and aryl/heteroaryl hydrazide… read more here.
Keywords: hydrazide based; cell lines; based analogs; hdac ... See more keywords
Modes of cell death induced by tetrahydroisoquinoline-based analogs in MDA-MB-231 breast and A549 lung cancer cell lines
Sign Up to like & getrecommendations! Published in 2018 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s152718
Abstract: Background A and B rings of the steroidal microtubule disruptor, 2-methoxyestradiol, and its analogs can be mimicked with a tetrahydroisoquinoline (THIQ) core. THIQs are cytotoxic agents with potential anticancer activities. The aim of this in… read more here.
Keywords: mda 231; cell death; based analogs; modes cell ... See more keywords
Fission Impossible: Stabilized miRNA-Based Analogs in Neurodegenerative Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.875957
Abstract: of exhibiting a specific down-regulation of brain-enriched miRNA in miRNA is a major in the most CA1 in findings read more here.
Keywords: analogs neurodegenerative; stabilized mirna; fission impossible; based analogs ... See more keywords
Non-Nucleoside Lycorine-Based Analogs as Potential DENV/ZIKV NS5 Dual Inhibitors: Structure-Based Virtual Screening and Chemoinformatic Analysis
Sign Up to like & getrecommendations! Published in 2024 at "Metabolites"
DOI: 10.3390/metabo14100519
Abstract: Dengue (DENV) and Zika (ZIKV) virus continue to pose significant challenges globally due to their widespread prevalence and severe health implications. Given the absence of effective vaccines and specific therapeutics, targeting the highly conserved NS5… read more here.
Keywords: denv; non nucleoside; lycorine based; nucleoside lycorine ... See more keywords