Studies on daptomycin lactam‐based analogues
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3430
Abstract: Herein, we report the synthesis and antibacterial evaluation of a series of daptomycin lactam‐based analogues. As compared with daptomycin, the daptomycin analogue with singly modified lactam has an eightfold increase in its minimum inhibitory concentration… read more here.
Keywords: antibacterial activity; based analogues; lactam based; daptomycin lactam ... See more keywords
Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.
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DOI: 10.1016/j.ejmech.2018.11.056
Abstract: Inhibition of the hedgehog (Hh) signaling pathway has been validated as a therapeutic strategy to treat basal cell carcinoma and holds potential for several other forms of human cancer. Itraconazole and posaconazole are clinically useful… read more here.
Keywords: hedgehog signaling; posaconazole based; based analogues; development posaconazole ... See more keywords
Crystalline radical cations of bis-BN-based analogues of Thiele's hydrocarbon.
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DOI: 10.1039/d2cc01254e
Abstract: Two radical cations of bis-BN-based analogues of Thiele's hydrocarbons were facilely synthesized, fully characterized, and theoretically investigated. One-electron oxidation leads to the reduced bond length alternation and NICS values of the central C4N2 rings, suggesting… read more here.
Keywords: bis based; cations bis; crystalline radical; analogues thiele ... See more keywords