Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.015
Abstract: New benzothiopyranoindoles (5a-l) and pyridothiopyranoindoles (5m-t), featuring different combinations of substituents (H, Cl, OCH3) at R2-R4 positions and protonatable R1-dialkylaminoalkyl chains, were synthesized and biologically assayed on three human tumor cell lines, showing significant antiproliferative… read more here.
Keywords: benzothiopyranoindole pyridothiopyranoindole; targeting topoisomerases; pyridothiopyranoindole based; antiproliferative agents ... See more keywords
Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026616666160530154812
Abstract: Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with… read more here.
Keywords: targeting tubulin; polymerization; tubulin polymerization; agents targeting ... See more keywords