Design and Optimization of Novel Benzimidazole- and Imidazo[4,5-b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities.
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DOI: 10.1021/acs.jmedchem.2c02104
Abstract: The ATM kinase is a promising target in cancer treatment as an important regulator of the cellular response to DNA double-strand breaks. In this work, we present a new class of specific benzimidazole-based ATM inhibitors… read more here.
Keywords: optimization novel; atm kinase; kinase; based atm ... See more keywords