Discovery of Potent and Selective Pyrrolo[2,3-d]Pyrimidine-Based Aurora A Inhibitors with Demonstrated Efficacy against Patient-Derived Gastric Cancer Organoids.
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DOI: 10.1021/acs.jmedchem.5c01886
Abstract: Aurora A kinase, a key regulator of mitosis, has emerged as a promising therapeutic target for gastric cancer. However, challenges related to selectivity and resistance highlight the urgent need for novel Aurora A inhibitors with… read more here.
Keywords: cancer; pyrrolo pyrimidine; based aurora; gastric cancer ... See more keywords