Targeting Hsc70-based autophagy to eliminate amyloid β oligomers.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.016
Abstract: Amyloid β (Aβ) oligomers may be a real culprit in the pathogenesis of Alzheimer's disease (AD); therefore, the elimination of these toxic oligomers may be of great significance for AD therapy. Autophagy is the catabolic… read more here.
Keywords: based autophagy; cma motifs; targeting hsc70; amyloid oligomers ... See more keywords
A dominant-negative regulatory mechanism of SQSTM1 droplets-based autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2029672
Abstract: ABSTRACT SQSTM1/p62 is an autophagy receptor, forming droplets to sequester intracellular polyubiquitinated cargo and mediate its delivery for autophagic clearance. SQSTM1 droplets can function as platforms to allow the formation of autophagosomes at their surfaces.… read more here.
Keywords: cleavage; sqstm1 droplets; sqstm1; dominant negative ... See more keywords
Development of a model to predict the prognosis of esophageal carcinoma based on autophagy-related genes.
Sign Up to like & getrecommendations! Published in 2022 at "Future oncology"
DOI: 10.2217/fon-2021-0070
Abstract: Aim: To identify a potential prognostic signature of esophageal carcinoma based on autophagy-related genes (ARGs). Methods: RNA sequencing and clinical data were downloaded from the Cancer Genome Atlas. Significantly different ARGs were identified by Wilcoxon signed-rank test. A prognostic… read more here.
Keywords: prognosis; esophageal carcinoma; model; autophagy related ... See more keywords
Editorial: Novel Cancer Treatments Based on Autophagy Modulation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.650559
Abstract: IMDEA Nanociencia, Ciudad Universitaria de Cantoblanco, Madrid, Spain, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, Verona, Italy, Department of… read more here.
Keywords: based autophagy; autophagy modulation; treatments based; cancer treatments ... See more keywords