Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-023-02285-4
Abstract: The pro-inflammatory ATP-gated P2X7 receptor is widely expressed by immune and non-immune cells. Nanobodies targeting P2X7, with potentiating or antagonistic effects, have been developed. Adeno-associated virus (AAV)-mediated gene transfer represents an efficient approach to achieve… read more here.
Keywords: p2x7; based biologics; nanobody based; vector coding ... See more keywords
Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1012534
Abstract: Adenosine triphosphate (ATP) represents a danger signal that accumulates in injured tissues, in inflammatory sites, and in the tumor microenvironment. ATP promotes tumor growth but also anti-tumor immune responses notably via the P2X7 receptor. ATP… read more here.
Keywords: based biologics; purinergic checkpoints; p2x7; nanobody based ... See more keywords
Long-Acting Extracellular Vesicle-Based Biologics in Osteoarthritis Immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Bioengineering"
DOI: 10.3390/bioengineering12050525
Abstract: Osteoarthritis (OA) is a chronic degenerative joint disease characterized by low-grade inflammation, cartilage breakdown, and persistent pain. Despite its prevalence, current therapeutic strategies primarily focus on symptom management rather than modifying disease progression. Monoclonal antibodies… read more here.
Keywords: acting extracellular; long acting; based biologics; vesicle based ... See more keywords