Micro RNA-371a-3p as a blood-based biomarker in testis cancer
Sign Up to like & getrecommendations! Published in 2021 at "Asian Journal of Urology"
DOI: 10.1016/j.ajur.2021.08.004
Abstract: Abstract MicroRNAs (miRNAs) are small noncoding RNAs involved in the regulation of mRNA transcription and translation, and possess all desirable features of an ideal tumor marker. Of almost 31 different miRNA clusters identified in germ… read more here.
Keywords: blood based; based biomarker; micro rna; mir 371a ... See more keywords
Mechanism-based biomarker discovery.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2017.04.013
Abstract: Biomarkers are cornerstones of healthcare spanning a wide spectrum of applications like disease diagnosis and stratification of patient populations. Despite significant efforts that have identified thousands of potential biomarkers, their translation into clinical practice remains… read more here.
Keywords: mechanism based; biomarker; biomarker discovery; based biomarker ... See more keywords
A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14020-9
Abstract: Alzheimer’s Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of… read more here.
Keywords: blood based; blood; biomarker panel; based biomarker ... See more keywords
A simulation study on implementing marginal structural models in an observational study with switching medication based on a biomarker
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1402783
Abstract: ABSTRACT Assessing treatment effectiveness in longitudinal data can be complex when treatments are not randomly assigned and patients are allowed to switch treatment to other or no treatment, often in a manner that is driven… read more here.
Keywords: based biomarker; treatment; study; marginal structural ... See more keywords
Towards the Clinical Implementation of Extracellular Vesicle-Based Biomarker Assays for Cancer.
Sign Up to like & getrecommendations! Published in 2024 at "Clinical chemistry"
DOI: 10.1093/clinchem/hvad189
Abstract: BACKGROUND Substantial research has been devoted to elucidating the role of extracellular vesicles (EVs) in the different hallmarks of cancer. Consequently, EVs are increasingly explored as a source of cancer biomarkers in body fluids. However,… read more here.
Keywords: cancer; based biomarker; clinical implementation; biomarker assays ... See more keywords
Alzheimer's disease blood-based biomarker testing: A stakeholder-informed assessment of coverage considerations
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877251329394
Abstract: Background Recently published clinical studies suggest that blood-based biomarker tests (BBMTs) for Alzheimer's disease (AD) provide value, but in the U.S., neither public nor private payers currently cover these tests. Objective To describe considerations for… read more here.
Keywords: alzheimer disease; disease; blood based; coverage ... See more keywords
A random forest based biomarker discovery and power analysis framework for diagnostics research
Sign Up to like & getrecommendations! Published in 2020 at "BMC Medical Genomics"
DOI: 10.1186/s12920-020-00826-6
Abstract: Background Biomarker identification is one of the major and important goal of functional genomics and translational medicine studies. Large scale –omics data are increasingly being accumulated and can provide vital means for the identification of… read more here.
Keywords: medicine; methodology; framework; biomarker ... See more keywords
CEA as a blood-based biomarker in anal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Oncotarget"
DOI: 10.18632/oncotarget.27959
Abstract: Background: The clinical utility of a blood-based biomarker in squamous cell carcinoma of the anus (SCCA) is unknown. We analyzed carcinoembryonic antigen (CEA), a commonly employed assay for patients with colorectal adenocarcinoma, as a serum… read more here.
Keywords: blood based; cea; disease; based biomarker ... See more keywords
Quantification of COX-2 Level in Alzheimer’s Disease Patients to Develop Potential Blood-Based Biomarker for Early Diagnosis and Therapeutic Target
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-231445
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disease and symptoms develop gradually over many years. The current direction for medication development in AD is focused on neuro-inflammation and oxidative stress. Amyloid-β (Aβ) deposition activates… read more here.
Keywords: alzheimer disease; disease; blood based; cox ... See more keywords
Challenges in the Metabolomics-Based Biomarker Validation Pipeline
Sign Up to like & getrecommendations! Published in 2024 at "Metabolites"
DOI: 10.3390/metabo14040200
Abstract: As end-products of the intersection between the genome and environmental influences, metabolites represent a promising approach to the discovery of novel biomarkers for diseases. However, many potential biomarker candidates identified by metabolomics studies fail to… read more here.
Keywords: challenges metabolomics; based biomarker; validation; biomarker validation ... See more keywords