Recent advances in platinum-based chemotherapeutics that exhibit inhibitory and targeted mechanisms of action.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111070
Abstract: Current platinum-based drugs used in chemotherapy, like cisplatin and its derivatives, are greatly limited due to side-effects and drug resistance. This has inspired the search for novel platinum-based drugs that deviate from the conventional mechanism… read more here.
Keywords: platinum based; advances platinum; based chemotherapeutics; recent advances ... See more keywords
Modulation of Glutamate Transporter EAAT1 and Inward-Rectifier Potassium Channel Kir4.1 Expression in Cultured Spinal Cord Astrocytes by Platinum-Based Chemotherapeutics
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22126300
Abstract: Platinum-based chemotherapeutics still play an essential role in cancer treatment. Despite their high effectiveness, severe side effects such as chemotherapy-induced neuropathy (CIPN) occur frequently. The pathophysiology of CIPN by platinum-based chemotherapeutics is not fully understood… read more here.
Keywords: cord astrocytes; platinum based; kir4; based chemotherapeutics ... See more keywords