Rolapitant for the prevention of nausea in patients receiving highly or moderately emetogenic chemotherapy
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DOI: 10.1002/cam4.1560
Abstract: Most patients receiving highly or moderately emetogenic chemotherapy experience chemotherapy‐induced nausea and vomiting without antiemetic prophylaxis. While neurokinin‐1 receptor antagonists (NK‐1RAs) effectively prevent emesis, their ability to prevent nausea has not been established. We evaluated… read more here.
Keywords: chemotherapy; highly moderately; patients receiving; receiving highly ... See more keywords
LINC00857 expression predicts and mediates the response to platinum‐based chemotherapy in muscle‐invasive bladder cancer
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DOI: 10.1002/cam4.1570
Abstract: Approximately 20% of patients with bladder cancer are diagnosed with muscle‐invasive disease (MIBC). The treatment involves radical cystectomy, but almost 50% of patients with MIBC eventually relapse and develop metastasis. The use of platinum‐based chemotherapy… read more here.
Keywords: chemotherapy; bladder cancer; platinum based; based chemotherapy ... See more keywords
Treatment outcomes of advanced/metastatic extramammary Paget's disease in Korean patients: KCSG-RC20-06.
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DOI: 10.1002/cam4.6190
Abstract: BACKGROUND Extramammary Paget's disease (EMPD) is rare. There are no standard treatments due to its rarity and few clinical trials. METHODS The objective of this multicenter study was to investigate treatment outcomes of Korean patients… read more here.
Keywords: taxane; treatment; advanced metastatic; chemotherapy ... See more keywords
Impact of DNA damage repair defects and aggressive variant features on response to carboplatin‐based chemotherapy in metastatic castration‐resistant prostate cancer
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DOI: 10.1002/ijc.33306
Abstract: Platinum‐based chemotherapy is not standard of care for unselected or genetically selected metastatic castration‐resistant prostate cancer (mCRPC) patients. A retrospective assessment of 71 patients was performed on platinum use in the Netherlands. Genetically unselected patients… read more here.
Keywords: platinum; response; prostate cancer; based chemotherapy ... See more keywords
Survival after neoadjuvant/induction combination immunotherapy vs combination platinum‐based chemotherapy for locally advanced (Stage III) urothelial cancer
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DOI: 10.1002/ijc.34125
Abstract: Despite treatment with cisplatin‐based chemotherapy and surgical resection, clinical outcomes of patients with locally advanced urothelial carcinoma (UC) remain poor. We compared neoadjuvant/induction platinum‐based combination chemotherapy (NAIC) with combination immune checkpoint inhibition (cICI). We identified… read more here.
Keywords: locally advanced; combination; stage iii; cici ... See more keywords
UGT1A polymorphisms associated with worse outcome in colorectal cancer patients treated with irinotecan-based chemotherapy
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DOI: 10.1007/s00280-018-3595-7
Abstract: PurposeTo investigate the association between UDP-glucuronosyltransferase (UGT)1A polymorphisms and irinotecan-treatment efficacy in a Chinese population with metastatic colorectal cancer (mCRC).MethodsThe present study was based on a prospective multicenter trial of Chinese mCRC patients treated with… read more here.
Keywords: treated irinotecan; irinotecan based; patients treated; colorectal cancer ... See more keywords
CDA and MTHFR polymorphisms are associated with clinical outcomes in gastroenteric cancer patients treated with capecitabine-based chemotherapy
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DOI: 10.1007/s00280-019-03809-2
Abstract: PurposeThe impact of pharmacogenetics on predicting survival in gastroenteric cancer remains unclear.MethodsWe tested 322 consecutive patients treated with capecitabine-based chemotherapy for CDA and MTHFR polymorphisms.ResultsPatients who carried the CDA 79 A>C (rs2072671) CC genotype showed… read more here.
Keywords: chemotherapy; capecitabine based; gastroenteric cancer; based chemotherapy ... See more keywords
Endothelial nitric oxide synthase c.-813C>T predicts for proteinuria in metastatic breast cancer patients treated with bevacizumab-based chemotherapy
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DOI: 10.1007/s00280-019-03933-z
Abstract: To investigate the association between single nucleotide polymorphisms (SNPs) in endothelial nitric oxide synthase (eNOS) and interleukin-8 (IL-8) genes and risk of developing bevacizumab-related adverse events in metastatic breast cancer (mBC) patients. mBC patients candidate… read more here.
Keywords: bevacizumab based; endothelial nitric; nitric oxide; based chemotherapy ... See more keywords
Forty years of cisplatin-based chemotherapy in muscle-invasive bladder cancer: are we understanding how, who and when?
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DOI: 10.1007/s00345-018-2544-8
Abstract: PurposeFor 40 years cisplatin-based chemotherapy has been administered to patients with muscle-invasive bladder cancer (MIBC). The best evidence of its efficacy is found in the context of neoadjuvant chemotherapy (NAC). However, the benefit to the… read more here.
Keywords: chemotherapy; invasive bladder; cisplatin based; muscle invasive ... See more keywords
Testicular cancer patients undergoing cisplatin based chemotherapy exhibit temporary olfactory threshold scores changes
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DOI: 10.1007/s00405-017-4559-y
Abstract: Testicular cancer is the most frequent malignant disease in young males between 15 and 35 years. Platinum based chemotherapy regimen is the therapy of choice in advanced disease. This treatment has also adverse effects caused by… read more here.
Keywords: testicular cancer; based chemotherapy; threshold scores; cancer ... See more keywords
Downregulation of topoisomerase 1 and 2 with acriflavine sensitizes bladder cancer cells to cisplatin-based chemotherapy.
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DOI: 10.1007/s11033-021-07087-1
Abstract: BACKGROUND Resistance to cisplatin is a major obstacle to effective treatment of bladder cancer (BC). The present study aimed to determine whether a combination of acriflavine (ACF) with cisplatin could potentiate the antitumor property of… read more here.
Keywords: based chemotherapy; cells cisplatin; cisplatin based; bladder cancer ... See more keywords