Structure‐based computational design of antibody mimetics: challenges and perspectives
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13855
Abstract: The design of antibody mimetics holds great promise for revolutionizing therapeutic interventions by offering alternatives to conventional antibody therapies. Structure‐based computational approaches have emerged as indispensable tools in the rational design of those molecules, enabling… read more here.
Keywords: structure based; design antibody; antibody mimetics; based computational ... See more keywords
Clinical Value of CT‐Based 3D Computational Modeling in Left Atrial Appendage Occlusion: An In‐Depth Analysis of the PRECISE LAAO Study
Sign Up to like & getrecommendations! Published in 2025 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.31464
Abstract: Standard of care (SoC) assessment based on computed tomography (CT) and/or transesophageal echocardiography is suboptimal for adequate preprocedural evaluation for left atrial appendage occlusion (LAAO). This can be improved through CT‐based 3D computational modeling of… read more here.
Keywords: computational modeling; left atrial; based computational; atrial appendage ... See more keywords
A database of 40 patient-based computational models for benchmarking organ dose estimates in CT.
Sign Up to like & getrecommendations! Published in 2020 at "Medical physics"
DOI: 10.1002/mp.14373
Abstract: PURPOSE Patient radiation burden in CT can best be characterized through risk estimates derived from organ doses. Organ doses can be estimated by Monte Carlo simulations of the CT procedures on computational phantoms assumed to… read more here.
Keywords: organ dose; organ doses; patient based; database ... See more keywords
On non‐stationary polarization methods in FFT‐based computational micromechanics
Sign Up to like & getrecommendations! Published in 2021 at "International Journal for Numerical Methods in Engineering"
DOI: 10.1002/nme.6812
Abstract: Polarization‐type methods are among the fastest solution methods for FFT‐based computational micromechanics. However, their performance depends critically on the choice of the reference material. Only for finitely contrasted materials, optimum‐selection strategies are known. This work… read more here.
Keywords: fft based; computational micromechanics; polarization; methods fft ... See more keywords
Web-Based Computational Tools for the Prediction and Analysis of Posttranslational Modifications of Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9055-9_1
Abstract: The increase in the number of Web-based resources on posttranslational modification sites (PTMSs) in proteins is accelerating. This chapter presents a set of computational protocols describing how to work with the Internet resources when dealing… read more here.
Keywords: web based; prediction analysis; computational tools; based computational ... See more keywords
On polarization-based schemes for the FFT-based computational homogenization of inelastic materials
Sign Up to like & getrecommendations! Published in 2019 at "Computational Mechanics"
DOI: 10.1007/s00466-019-01694-3
Abstract: We revisit the polarization-based schemes introduced to FFT-based computational homogenization by Eyre–Milton, Michel–Moulinec–Suquet and Monchiet–Bonnet. When applied to nonlinear problems, these polarization-based methods suffer from two handicaps. Firstly, the optimal choice of algorithmic parameters is… read more here.
Keywords: based computational; computational homogenization; based schemes; polarization based ... See more keywords
A dynamical view of nonlinear conjugate gradient methods with applications to FFT-based computational micromechanics
Sign Up to like & getrecommendations! Published in 2020 at "Computational Mechanics"
DOI: 10.1007/s00466-020-01849-7
Abstract: For fast Fourier transform (FFT)-based computational micromechanics, solvers need to be fast, memory-efficient, and independent of tedious parameter calibration. In this work, we investigate the benefits of nonlinear conjugate gradient (CG) methods in the context… read more here.
Keywords: fft based; computational micromechanics; conjugate gradient; based computational ... See more keywords
A CNN-based computational algorithm for nonlinear image diffusion problem
Sign Up to like & getrecommendations! Published in 2020 at "Multimedia Tools and Applications"
DOI: 10.1007/s11042-020-09077-0
Abstract: In the past, several partial differential equations (PDEs) based methods have been widely studied in image denoising. While solving these methods numerically, some parameters need to be chosen manually. This paper proposes a cellular neural… read more here.
Keywords: image; diffusion; computational algorithm; algorithm nonlinear ... See more keywords
Theory-Based Computational Psychiatry
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DOI: 10.1016/j.biopsych.2017.07.016
Abstract: Philosophy [nature] is written in that great book which ever lies before our eyes—I mean the universe—but we cannot understand it if we do not first learn the language.in which it is written. This book… read more here.
Keywords: psychiatry theory; computational psychiatry; theory based; philosophy ... See more keywords
A deep learning-based computational approach for discrimination of DNA N6-methyladenosine sites by fusing heterogeneous features
Sign Up to like & getrecommendations! Published in 2020 at "Chemometrics and Intelligent Laboratory Systems"
DOI: 10.1016/j.chemolab.2020.104151
Abstract: Abstract N6-methyladenine is post-replication modifications, which take place in the extensive range of DNA sequences and involved with a large number of different bioprocesses such as DNA repair, replication, cellular defense, and transcription in prokaryotes.… read more here.
Keywords: computational approach; dna; deep learning; learning based ... See more keywords
Estimation of obesity levels based on computational intelligence
Sign Up to like & getrecommendations! Published in 2020 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2020.100472
Abstract: Abstract Obesity is a worldwide disease that affects people of all ages and gender; in consequence, researchers have made great efforts to identify factors that cause it early. In this study, an intelligent method is… read more here.
Keywords: based computational; computational intelligence; obesity levels; levels based ... See more keywords