Quantifying immune-based counterselection of somatic mutations
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DOI: 10.1371/journal.pgen.1008227
Abstract: Somatic mutations in protein-coding regions can generate ‘neoantigens’ causing developing cancers to be eliminated by the immune system. Quantitative estimates of the strength of this counterselection phenomenon have been lacking. We quantified the extent to… read more here.
Keywords: based counterselection; counterselection somatic; somatic mutations; counterselection ... See more keywords