Fragment‐Based Design, Synthesis, and Biological Evaluation of 1‐Substituted‐indole‐2‐carboxylic Acids as Selective Mcl‐1 Inhibitors
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DOI: 10.1002/ardp.201600251
Abstract: Based on a known selective Mcl‐1 inhibitor, 6‐chloro‐3‐(3‐(4‐chloro‐3,5‐dimethylphenoxy)propyl)‐1H‐indole‐2‐carboxylic acid, we applied a fragment‐based approach to obtain new molecules that extended into the p1 pocket of the BH3 groove and then exhibited binding selectivity for the… read more here.
Keywords: mcl; indole carboxylic; selective mcl; fragment based ... See more keywords
Structure‐Based Design of a New Scaffold for Cell‐Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8
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DOI: 10.1002/cbic.201700109
Abstract: The histone demethylase PHF8 catalyzes demethylation of mono‐ and di‐methylated Lys9 on histone H3 (H3K9me1/2), and is a transcriptional activator involved in the development and cancer. Affinity and specificity of PHF8 towards H3K9me2 is affected… read more here.
Keywords: demethylase phf8; histone demethylase; structure based; cell penetrating ... See more keywords
Structure‐Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits
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DOI: 10.1002/cbic.202000375
Abstract: Proteasomes are established therapeutic targets for hematological cancers and promising targets for autoimmune diseases. In the past, we have designed and synthesized mechanism‐based proteasome inhibitors that are selective for the individual catalytic activities of human… read more here.
Keywords: design fluorogenic; proteasome; structure based; based design ... See more keywords
Structure-Based Design of Diagnostics and Vaccines for Lyme Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1884-4_21
Abstract: Changes in climate have increased the geographical range of insect vectors responsible for the transmission of several diseases. Lyme disease, caused by the bacterial pathogen Borrelia burgdorferi, has become recognized as the most prevalent arthropod-borne… read more here.
Keywords: based design; structure based; lyme disease; disease ... See more keywords
An improved two-stage framework of evidence-based design optimization
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DOI: 10.1007/s00158-018-1991-6
Abstract: In this paper, an improved two-stage framework is presented to handle the evidence-based design optimization (EBDO) problem under epistemic uncertainty. The improvements include two aspects: (1) in the first stage, the equal areas method is… read more here.
Keywords: framework; evidence; design optimization; optimization ... See more keywords
A new efficient decoupled reliability-based design optimization method with quantiles
Sign Up to like & getrecommendations! Published in 2019 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-019-02384-7
Abstract: The problems of reliability-based design optimization (RBDO) can generally be solved by double-loop methods, single-loop methods or decoupled methods. The sequence optimization and reliability assessment (SORA) method is a widely used decoupled method due to… read more here.
Keywords: reliability based; method; design optimization; optimization ... See more keywords
A new efficient hybrid approach for reliability-based design optimization problems
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DOI: 10.1007/s00366-020-01187-5
Abstract: The reliability-based design optimization (RBDO) is performed for mechanical design to compromise effectively between economy and safety requirements. In real mechanical applications, such RBDO problems are a highly complex task by involving computational difficulties and… read more here.
Keywords: reliability based; optimization; based design; approach ... See more keywords
Model-Based Design of Flexible and Efficient LDPC Decoders on FPGA Devices
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DOI: 10.1007/s11265-020-01519-0
Abstract: Advances in digital communication advocate for the use of hardware LDPC decoders in applications requiring reliable and fast information transfer. Hand-coded RTL architectures provide the highest performances but slower the path to IP design. By… read more here.
Keywords: based design; ldpc; ldpc decoders; model based ... See more keywords
T–S fuzzy observed based design and synchronization of chaotic and hyper-chaotic dynamical systems
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DOI: 10.1007/s40435-017-0358-y
Abstract: In this paper, we present the Takagi–Sugeno (T–S) fuzzy observed based design and synchronization of chaotic and hyper chaotic dynamical systems. Using T–S fuzzy observed based design, the fuzzy logic controllers for chaotic synchronization are… read more here.
Keywords: hyper chaotic; chaotic hyper; observed based; based design ... See more keywords
Desirability-Based Design of Space Structures Using Genetic Algorithm and Fuzzy Logic
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DOI: 10.1007/s40999-016-0103-5
Abstract: Engineering design usually considers multiple variances in a design and integrates them appropriately to achieve the most desirable alternatives. This concern is of particular importance in civil engineering construction projects. Frequently, the considerations of the… read more here.
Keywords: engineering; desirability based; based design; fuzzy logic ... See more keywords
Numerical simulation based design for an innovative PEMFC cooling flow field with metallic bipolar plates
Sign Up to like & getrecommendations! Published in 2018 at "Applied Energy"
DOI: 10.1016/j.apenergy.2018.06.101
Abstract: Abstract Polymer electrolyte membrane fuel cells (PEMFC) can be a promising energy source if optimal thermal management is provided, and also manufacturing cost is reduced for mass production. These are the main goals researchers have… read more here.
Keywords: based design; metallic bipolar; simulation based; bipolar plates ... See more keywords