Diagnosis of infectionMolecular-based diagnostics, including future trends
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1016/j.mpmed.2017.07.004
Abstract: Microbiological diagnosis has traditionally relied on phenotypic methods involving culture and biochemical testing to identify and characterize clinically relevant pathogens. These techniques have several disadvantages including poor sensitivity and long turn-around time. Molecular and mass… read more here.
Keywords: future trends; diagnostics including; including future; diagnosis infectionmolecular ... See more keywords
CRISPR-Cas12a-Based Diagnostics of Wheat Fungal Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c08391
Abstract: Fusarium head blight (FHB) of wheat, mainly caused by Fusarium graminearum (F. graminearum) infection, reduces crop yield and contaminates grain with mycotoxins. We report a clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a-based nucleic acid assay… read more here.
Keywords: cas12a based; based diagnostics; diagnostics wheat; wheat fungal ... See more keywords
Data-Driven Approaches Can Overcome the Cost-Accuracy Trade-off in Multireference Diagnostics.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.0c00358
Abstract: High-throughput computational screening typically employs methods (i.e., density functional theory or DFT) that can fail to describe challenging molecules, such as those with strongly correlated electronic structure. In such cases, multireference (MR) correlated wavefunction theory… read more here.
Keywords: dft based; cost accuracy; accuracy trade; based diagnostics ... See more keywords
Nanotechnology Based Diagnostics and Therapy for Pathogens- Related Infections in the CNS.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00470
Abstract: The central nervous system (CNS) encompasses the brain, spinal cord, and nerves, where both brain and spinal cord are safeguarded by the meninges. However, serious bacterial, viral or fungal infection in the brain causes life-threatening… read more here.
Keywords: diagnostics therapy; therapy pathogens; nanotechnology; nanotechnology based ... See more keywords
External Validation of Population Pharmacokinetic Models of Lamotrigine in Patients with Epilepsy or Postneurosurgery.
Sign Up to like & getrecommendations! Published in 2025 at "Therapeutic drug monitoring"
DOI: 10.1097/ftd.0000000000001322
Abstract: BACKGROUND This study aimed to evaluate the predictive performance of published lamotrigine (LTG) population pharmacokinetic (PPK) models using an external data set of Chinese patients with epilepsy or postneurosurgery. METHODS In total, 348 concentration measurements… read more here.
Keywords: population pharmacokinetic; patients epilepsy; epilepsy postneurosurgery; based diagnostics ... See more keywords
Recommendations to improve the clinical adoption of NGS‐based cancer diagnostics in Singapore
Sign Up to like & getrecommendations! Published in 2020 at "Asia-Pacific Journal of Clinical Oncology"
DOI: 10.1111/ajco.13339
Abstract: Next‐generation sequencing (NGS)‐based diagnostics have demonstrated clinical utility in predicting improved survival benefits with targeted treatment in certain cancer types, and positive cost–benefit in several healthcare systems. However, clinical adoption in Singapore remains low despite… read more here.
Keywords: clinical adoption; ngs based; adoption ngs; cancer ... See more keywords
Implications of Using Host Response-Based Molecular Diagnostics on the Management of Bacterial and Viral Infections: A Review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.805107
Abstract: Host-based diagnostics are a rapidly evolving field that may serve as an alternative to traditional pathogen-based diagnostics for infectious diseases. Understanding the exact mechanisms underlying a host-immune response and deriving specific host-response signatures, biomarkers and… read more here.
Keywords: based diagnostics; host response; using host; host ... See more keywords
External Evaluation of Population Pharmacokinetic Models of Busulfan in Chinese Adult Hematopoietic Stem Cell Transplantation Recipients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.835037
Abstract: Objective: Busulfan (BU) is a bi-functional DNA-alkylating agent used in patients undergoing hematopoietic stem cell transplantation (HSCT). Over the last decades, several population pharmacokinetic (pop PK) models of BU have been established, but external evaluation… read more here.
Keywords: external evaluation; based diagnostics; prediction; hematopoietic stem ... See more keywords
Leveraging Blood-Based Diagnostics to Predict Tumor Biology and Extend the Application and Personalization of Radiotherapy in Liver Cancers
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23041926
Abstract: While the incidence of primary liver cancers has been increasing worldwide over the last few decades, the mortality has remained consistently high. Most patients present with underlying liver disease and have limited treatment options. In… read more here.
Keywords: liver cancers; based diagnostics; blood based; blood ... See more keywords
Advancements in LAMP-Based Diagnostics: Emerging Techniques and Applications in Viral Detection with a Focus on Herpesviruses in Transplant Patient Management
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252111506
Abstract: Loop-mediated isothermal amplification (LAMP) is a highly effective molecular diagnostic technique, particularly advantageous for point-of-care (POC) settings. In recent years, LAMP has expanded to include various adaptations such as DARQ-LAMP, QUASR, FLOS-LAMP, displacement probes and… read more here.
Keywords: detection; based diagnostics; diagnostics emerging; emerging techniques ... See more keywords
CRISPR-Based Diagnostics: A Potential Tool to Address the Diagnostic Challenges of Tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11101211
Abstract: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which infects more than 23% of the world’s population. With the emergence of drug-resistant TB (DR-TB) and latent TB infection (LTBI), rapid diagnosis of DR-TB… read more here.
Keywords: based diagnostics; diagnosis; potential tool; crispr based ... See more keywords