A highly sensitive and selective high pressure liquid chromatography with tandem mass spectrometry (HPLC/MS-MS) method for the direct peptide reactivity assay (DPRA).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2018.07.004
Abstract: While the HPLC/UV (high performance liquid chromatography coupled with ultra-violet spectrometry)-based DPRA (Direct Peptide Reactivity Assay) identifies dermal sensitizers with approximately 80% accuracy, the low selectivity and sensitivity of the HPLC/UV-based DPRA poses challenges to… read more here.
Keywords: based dpra; liquid chromatography; hplc based;