Fragment‐based drug discovery—the importance of high‐quality molecule libraries
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13277
Abstract: Fragment‐based drug discovery (FBDD) is now established as a complementary approach to high‐throughput screening (HTS). Contrary to HTS, where large libraries of drug‐like molecules are screened, FBDD screens involve smaller and less complex molecules which,… read more here.
Keywords: fragment based; drug discovery; based drug; discovery importance ... See more keywords
Living Leukocyte‐Based Drug Delivery Systems
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202207787
Abstract: Leukocytes play a vital role in immune responses, including defending against invasive pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the immune system is activated in vivo, leukocytes accomplish a series of orderly and… read more here.
Keywords: living leukocyte; delivery systems; drug delivery; based drug ... See more keywords
Agarose bioplastic‐based drug delivery system for surgical and wound dressings
Sign Up to like & getrecommendations! Published in 2017 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201500116
Abstract: We have developed an agarose‐based biocompatible drug delivery vehicle. The vehicle is in the form of thin, transparent, strong and flexible films. The biocompatibility and haemocompatibility of the films is confirmed using direct and indirect… read more here.
Keywords: agarose bioplastic; drug delivery; drug; bioplastic based ... See more keywords
Identification of novel inhibitors for Prp protein of Mycobacterium tuberculosis by structure based drug design, and molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26823
Abstract: In this study, we assess the effective inhibition of a series of thiazolidine derivatives (1a–1q) were adopting structure‐based drug design. Thiazolidine is a five‐membered ring structure with thioether and amino groups at positions 1 and… read more here.
Keywords: structure; tuberculosis; chemistry; drug design ... See more keywords
A cell-based drug delivery platform for treating central nervous system inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-020-02003-9
Abstract: Mesenchymal stem cells (MSCs) are promising candidates for the development of cell-based drug delivery systems for autoimmune inflammatory diseases, such as multiple sclerosis (MS). Here, we investigated the effect of Ro-31-8425, an ATP-competitive kinase inhibitor,… read more here.
Keywords: drug delivery; cell; mscs; based drug ... See more keywords
An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2531-1
Abstract: PurposeThree-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has been used to… read more here.
Keywords: technologies soft; soft materials; lipid based; drug delivery ... See more keywords
A novel amorphous solid dispersion based on drug-polymer complexation.
Sign Up to like & getrecommendations! Published in 2020 at "Drug delivery and translational research"
DOI: 10.1007/s13346-020-00869-3
Abstract: Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP… read more here.
Keywords: raf; drug polymer; complexation; drug ... See more keywords
Model-based drug development: application of modeling and simulation in drug development
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-017-0371-3
Abstract: Despite enormous success in biomedical science and technology, as well as increased research and development spending, pharmaceutical productivity has faced challenges. The success rates in drug development remain low and have shown a declining trend… read more here.
Keywords: drug development; modeling simulation; model based; development ... See more keywords
Recent Advances in the Implant-based Drug Delivery in Otorhinolaryngology.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.04.012
Abstract: The surgical implant is an interdisciplinary therapeutic modality that offers unique advantages in the daily practice of otorhinolaryngology. Some well-known examples include cochlear implants, bone-anchored hearing aids, sinus stents, and tracheostomy tubes. Neuroprotective, osteogenic, anti-inflammatory,… read more here.
Keywords: implant based; drug delivery; delivery; otorhinolaryngology ... See more keywords
Lipoprotein-based drug delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2020.08.003
Abstract: Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound… read more here.
Keywords: drug delivery; delivery; drug; lipoprotein based ... See more keywords
Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109568
Abstract: Malignant rhabdoid tumors (MRTs) represent one of the most aggressive childhood malignancies. No effective treatment options are available, and prognosis is, therefore, dismal. Previous studies have demonstrated that tumor organoids capture the heterogeneity of patient… read more here.
Keywords: rhabdoid tumors; malignant rhabdoid; drug screening; organoid based ... See more keywords