MiRNA-based drugs: challenges and delivery strategies
Sign Up to like & getrecommendations! Published in 2025 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-025-13620-0
Abstract: The miRNA-based therapeutics held great promise for the treatment of diseases associated with aberrant gene expression. However, the development of miRNA-based drugs still faces many obstacles, including stability, targetability, tissue penetration, and induction of immune… read more here.
Keywords: based drugs; mirna based; delivery; delivery systems ... See more keywords
Recent Trends in Clinical Trials Related to Carrier-Based Drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.02.026
Abstract: Clinical trials related to carrier-based drugs have recently attracted attention because carrier-based drugs hold promise for high efficiency drug delivery and for reducing drug-related side effects. In this commentary, we introduce recent clinical trials involving… read more here.
Keywords: trials related; carrier based; related carrier; clinical trials ... See more keywords
Targeting Glioblastoma: Efficacy of Ruthenium-Based Drugs.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00188
Abstract: Ruthenium compounds offer improved selectivity and fewer side effects compared to platinum-based drugs in glioblastoma treatment. Insights into their interactions with transferrin suggest targeted drug delivery, while photoactivated chemotherapy is a novel cytotoxic approach in… read more here.
Keywords: ruthenium; based drugs; targeting glioblastoma; glioblastoma efficacy ... See more keywords
Substance P Mediated DGLs Complexing with DACHPt for Targeting Therapy of Glioma.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b05997
Abstract: Currently, glioblastoma (glioma) is described as the deadliest brain tumor for its invasive natural with exceeding difficulty in surgical excision. Blood-brain barrier (BBB) can restrict the penetration of most therapeutic reagents including platinum (Pt)-based drugs-the… read more here.
Keywords: substance mediated; glioma; dachpt; mediated dgls ... See more keywords
Nanoparticle-Based Drugs and Formulations: Current Status and Emerging Applications
Sign Up to like & getrecommendations! Published in 2020 at "ACS Applied Nano Materials"
DOI: 10.1021/acsanm.0c00606
Abstract: In the foreseeable future, pharmaceuticals market, nanomedicine and healthcare system will largely depend on the drug nanoparticles formulation technology. Perceiving this, a significant amount of ... read more here.
Keywords: current status; nanoparticle based; formulations current; drugs formulations ... See more keywords
Comparative NMR metabolomics of the responses of A2780 human ovarian cancer cells to clinically established Pt-based drugs.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt02068h
Abstract: Pt-Based drugs play a very important role in current cancer treatments; yet, their cellular and mechanistic aspects are not fully understood. NMR metabolomics provides a powerful tool to investigate the metabolic perturbations induced by Pt… read more here.
Keywords: cancer; cancer cells; nmr metabolomics; responses a2780 ... See more keywords
A new therapeutic perspective on metal-based drugs.
Sign Up to like & getrecommendations! Published in 2025 at "Dalton transactions"
DOI: 10.1039/d5dt01567g
Abstract: Metal-based drugs have been at the forefront of research and development in laboratories around the world for several decades. Within the area of medicinal inorganic chemistry, many potential pharmaceuticals have been obtained and evaluated, with… read more here.
Keywords: based drugs; metal based; therapeutic perspective; new therapeutic ... See more keywords
Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000599
Abstract: Purpose of review Several members of the fibroblast growth factor (FGF) family have been identified as key regulators of energy metabolism in rodents and nonhuman primates. Translational studies show that their metabolic actions are largely… read more here.
Keywords: growth factors; fgf based; fibroblast growth; metabolism ... See more keywords
Prescribing cannabis based drugs: response from NICE and Health Education England
Sign Up to like & getrecommendations! Published in 2018 at "British Medical Journal"
DOI: 10.1136/bmj.k4940
Abstract: Further to Hamilton’s recommendation that general practitioners consult Google Scholar and ask their colleagues if they are unsure about prescribing cannabis,1 we write to remind readers in England that they have 24/7 access to reliable… read more here.
Keywords: cannabis based; evidence; drugs response; health ... See more keywords
Platinum-Based Drugs Differentially Affect the Ultrastructure of Breast Cancer Cell Types
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/3178794
Abstract: Breast cancer (BC) is the most common cause of cancer-related death worldwide. Although platinum-based drugs (PBDs) are effective anticancer agents, responsive patients eventually become resistant. While resistance of some cancers to PBDs has been explored,… read more here.
Keywords: platinum based; breast cancer; cancer; cell ... See more keywords
Fumarate-based drugs protect against neuroinflammation via upregulation of anti-ferroptotic pathways
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-025-03592-3
Abstract: Ferroptosis is defined as iron dependent non-apoptotic cell death. It is based on peroxidation of polyunsaturated phospholipids and subsequent membrane rupture. Lipid peroxidation is induced mainly by the hydroxyl radical, the product of the Fenton… read more here.
Keywords: based drugs; protect neuroinflammation; neuroinflammation; fumarate based ... See more keywords