Creatinine-based estimated glomerular filtration rate for children younger than 2 years
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-017-1460-3
Abstract: To the Editor Serum creatinine (Cr)-based eGFR may be used for Japanese children aged 2–18 years to evaluate renal function, measuring serum Cr by enzymatic method [1]. In clinical practice, cystatin C (cysC)-based eGFR [2]… read more here.
Keywords: estimated glomerular; younger years; creatinine based; children aged ... See more keywords
Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01041
Abstract: Activating mutations in the epidermal growth factor receptor (EGFR) are frequent oncogenic drivers of non-small-cell lung cancer (NSCLC). The most frequent alterations in EGFR are short in-frame deletions in exon 19 (Del19) and the missense… read more here.
Keywords: macrocyclization quinazoline; based egfr; egfr inhibitors; quinazoline ... See more keywords