Massively Parallel CRISPR‐Based Genetic Perturbation Screening at Single‐Cell Resolution
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204484
Abstract: The clustered regularly interspaced short palindromic repeats (CRISPR)‐based genetic screening has been demonstrated as a powerful approach for unbiased functional genomics research. Single‐cell CRISPR screening (scCRISPR) techniques, which result from the combination of single‐cell toolkits… read more here.
Keywords: cell; resolution; single cell; based genetic ... See more keywords
Optimization of Canal Water in an Irrigation Network Based on a Genetic Algorithm: A Case Study of the North China Plain Canal System
Sign Up to like & getrecommendations! Published in 2019 at "Irrigation and Drainage"
DOI: 10.1002/ird.2345
Abstract: Maximizing the efficiency of water distribution in canals requires clear guidelines and criteria for system design and operation. Studies have shown that optimization models based on a genetic algorithm (GA) provide a reasonable arrangement of… read more here.
Keywords: system; canal system; genetic algorithm; based genetic ... See more keywords
Multivariate, region‐based genetic analyses of facets of reproductive aging in White and Black women
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1896
Abstract: Age at final menstrual period (FMP) and the accompanying hormone trajectories across the menopause transition do not occur in isolation, but likely share molecular pathways. Understanding the genetics underlying the endocrinology of the menopause transition… read more here.
Keywords: genetic analyses; analyses facets; based genetic; multivariate region ... See more keywords
Hierarchical optimization of the composite blade of a stratospheric airship propeller based on genetic algorithm
Sign Up to like & getrecommendations! Published in 2017 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-017-1725-1
Abstract: High-altitude propellers equipped with solar energy systems are widely adopted in stratospheric airships because of their light weight, excellent mechanical performance, and high efficiency. To optimize the composite laminated structure of the blade, a hierarchical… read more here.
Keywords: hierarchical optimization; stratospheric airship; genetic algorithm; optimization ... See more keywords
Improving the efficiency of dissolved oxygen control using an on-line control system based on a genetic algorithm evolving FWNN software sensor.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of environmental management"
DOI: 10.1016/j.jenvman.2016.10.056
Abstract: This work proposes an on-line hybrid intelligent control system based on a genetic algorithm (GA) evolving fuzzy wavelet neural network software sensor to control dissolved oxygen (DO) in an anaerobic/anoxic/oxic process for treating papermaking wastewater.… read more here.
Keywords: system; control; genetic algorithm; system based ... See more keywords
Virtual machine placement strategy using cluster-based genetic algorithm
Sign Up to like & getrecommendations! Published in 2021 at "Neurocomputing"
DOI: 10.1016/j.neucom.2020.06.120
Abstract: Abstract The problem of virtual machine (VM) live migration in self-driving systems targets reallocating resources among VMs running different self-driving services for load balance. It is of great importance to enable a running VM to… read more here.
Keywords: virtual machine; genetic algorithm; cluster based; problem ... See more keywords
Optimization of texture shape based on Genetic Algorithm under unidirectional sliding
Sign Up to like & getrecommendations! Published in 2017 at "Tribology International"
DOI: 10.1016/j.triboint.2017.05.017
Abstract: Abstract A numerical approach was proposed for the optimization of shape contour of recessed surface texture under unidirectional sliding. The approach was developed based on a Genetic Algorithm to improve the tribological performance. Results indicated… read more here.
Keywords: texture shape; shape; genetic algorithm; unidirectional sliding ... See more keywords
Surrogate Based Genetic Algorithm Method for Efficient Identification of Low-Energy Peptide Structures
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.2c01078
Abstract: Identification of the most stable structure(s) of a system is a prerequisite for the calculation of any of its properties from first-principles. However, even for relatively small molecules, exhaustive explorations of the potential energy surface… read more here.
Keywords: low energy; surrogate based; energy; identification ... See more keywords
Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2018.6
Abstract: Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort read more here.
Keywords: genetic discovery; combining linkage; discovery combining; employed family ... See more keywords
An efficient local search-based genetic algorithm for constructing optimal Latin hypercube design
Sign Up to like & getrecommendations! Published in 2019 at "Engineering Optimization"
DOI: 10.1080/0305215x.2019.1584618
Abstract: ABSTRACT Latin hypercube design (LHD) is a multi-stratified sampling method, which has been frequently used in sampling-based analysis. To achieve good space-filling quality of LHD, an efficient method, termed local search-based genetic algorithm (LSGA), is… read more here.
Keywords: based genetic; latin hypercube; search based; hypercube design ... See more keywords
A promising subgroup identification method based on a genetic algorithm for censored survival data.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2023.2170397
Abstract: Modern precision medicine requires drug development to account for patients' heterogeneity, as only a subgroup of the patient population is likely to benefit from the targeted therapy. In this paper, we propose a novel method… read more here.
Keywords: subgroup identification; genetic algorithm; based genetic; method ... See more keywords