Metabolome-Based Genome-Wide Association Study of Duck Meat Leads to Novel Genetic and Biochemical Insights.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300148
Abstract: Meat is among the most consumed foods worldwide and has a unique flavor and high nutrient density in the human diet. However, the genetic and biochemical bases of meat nutrition and flavor are poorly understood.… read more here.
Keywords: metabolome based; based genome; genome wide; wide association ... See more keywords
First insight into the phylogeny of fine‐leaved Festuca in the Altai Mountain Country based on genome‐wide genotyping
Sign Up to like & getrecommendations! Published in 2023 at "Ecology and Evolution"
DOI: 10.1002/ece3.9943
Abstract: Abstract Festuca is one of the largest genera within the Poaceae family. Molecular phylogenies demonstrate that Festuca s.l. comprises two groups: broad‐ and fine‐leaved species. The latter is the species‐richest and taxonomically complicated group due… read more here.
Keywords: based genome; genome wide; first insight; insight phylogeny ... See more keywords
A Family-Based Genome Wide Association Study of Externalizing Behaviors
Sign Up to like & getrecommendations! Published in 2020 at "Behavior Genetics"
DOI: 10.1007/s10519-020-09999-3
Abstract: Shared genetic factors contribute to the high degree of comorbidity among externalizing problems (e.g. substance use and antisocial behavior). We leverage this common genetic etiology to identify genetic influences externalizing problems in participants from the… read more here.
Keywords: genome wide; study; externalizing problems; ancestry ... See more keywords
Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103436
Abstract: Background Due to the molecular mechanism complexity and heterogeneity of gastric cancer (GC), mechanistically interpretable biomarkers were required for predicting prognosis and discovering therapeutic targets for GC patients. Methods Based on a total of 824… read more here.
Keywords: genome wide; gastric cancer; model; therapeutic target ... See more keywords
Metabolic Blockade-Based Genome Mining Reveals Lipochain-Linked Dihydro-β-alanine Synthetases Involved in Autucedine Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01957
Abstract: Continuously mining the Streptomyces olivaceus SCSIO T05 genome leads to the identification of new lipopeptides (autucedines A-C), constituting members of the 10th skeleton isolated from this strain. The corresponding biosynthetic gene cluster (aut) was verified… read more here.
Keywords: metabolic blockade; based genome; blockade based; dihydro alanine ... See more keywords
A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life
Sign Up to like & getrecommendations! Published in 2018 at "Nature Biotechnology"
DOI: 10.1038/nbt.4229
Abstract: Taxonomy is an organizing principle of biology and is ideally based on evolutionary relationships among organisms. Development of a robust bacterial taxonomy has been hindered by an inability to obtain most bacteria in pure culture… read more here.
Keywords: taxonomy; standardized bacterial; taxonomy based; genome phylogeny ... See more keywords
Advances in off-target detection for CRISPR-based genome editing.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2022.198
Abstract: The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based genome editing system exhibits marked potential for both gene editing and gene therapy, and its continuous improvement contributes to its great clinical potential. However, the largest hindrance… read more here.
Keywords: genome editing; based genome; advances target; detection ... See more keywords
Metabolite‐based genome‐wide association study enables dissection of the flavonoid decoration pathway of wheat kernels
Sign Up to like & getrecommendations! Published in 2020 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.13335
Abstract: Summary The marriage of metabolomic approaches with genetic design has proven a powerful tool in dissecting diversity in the metabolome and has additionally enhanced our understanding of complex traits. That said, such studies have rarely… read more here.
Keywords: genome wide; wheat kernels; study; metabolite based ... See more keywords
Identification of resistance loci in Chinese and Canadian canola/rapeseed varieties against Leptosphaeria maculans based on genome-wide association studies
Sign Up to like & getrecommendations! Published in 2020 at "BMC Genomics"
DOI: 10.1186/s12864-020-06893-4
Abstract: The fungal pathogen Leptosphaeria maculans (Lm). causes blackleg disease on canola/rapeseed in many parts of the world. It is important to use resistant cultivars to manage the disease and minimize yield losses. In this study,… read more here.
Keywords: genome wide; canola rapeseed; resistance; leptosphaeria maculans ... See more keywords
Basic Principles and Clinical Applications of CRISPR-Based Genome Editing
Sign Up to like & getrecommendations! Published in 2022 at "Yonsei Medical Journal"
DOI: 10.3349/ymj.2022.63.2.105
Abstract: Advances in sequencing technologies have facilitated the discovery of previously unknown genetic variants in both inherited and acquired disorders, and tools to correct these pathogenic variants are rapidly evolving. Since the first introduction of CRISPR-Cas9… read more here.
Keywords: genome editing; clinical applications; based genome; basic principles ... See more keywords
CRISPR-Based Genome Editing for Nutrient Enrichment in Crops: A Promising Approach Toward Global Food Security
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.932859
Abstract: The global malnutrition burden imparts long-term developmental, economic, social, and medical consequences to individuals, communities, and countries. The current developments in biotechnology have infused biofortification in several food crops to fight malnutrition. However, these methods… read more here.
Keywords: genome editing; crispr; based genome; food ... See more keywords