VSS: Variance-stabilized signals for sequencing-based genomic signals.
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab457
Abstract: MOTIVATION A sequencing-based genomic assay such as ChIP-seq outputs a real-valued signal for each position in the genome that measures the strength of activity at that position. Most genomic signals lack the property of variance… read more here.
Keywords: stabilized signals; variance stabilized; genomic signals; variance ... See more keywords
A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy
Sign Up to like & getrecommendations! Published in 2024 at "Bju International"
DOI: 10.1111/bju.16572
Abstract: To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a… read more here.
Keywords: radical cystectomy; non coding; genomic classifier; bladder cancer ... See more keywords
Clinical utility of next-generation sequencing (NGS)-based genomic profiling of advanced solid tumors in routine clinical practice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e24157
Abstract: e24157Background: Next-generation sequencing (NGS)-based genomic profiling of advanced solid tumors has given a new perspective to personalized patient care in oncology. In a single run, NGS allows... read more here.
Keywords: sequencing ngs; ngs based; next generation; oncology ... See more keywords
Illustration of temporal evolution in patients with metastatic renal cell carcinoma (mRCC) using both circulating tumor DNA (ctDNA) and tissue-based genomic data.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.6_suppl.347
Abstract: 347Background: We have previously demonstrated the feasibility of ctDNA assessment in mRCC and preliminarily showed agreement between ctDNA and tissue-based genomic findings (Zengin et al ESMO 2020... read more here.
Keywords: tissue based; based genomic; ctdna; mrcc ... See more keywords
A Deep Autoencoder Compression-Based Genomic Prediction Method for Whole-Genome Sequencing Data
Sign Up to like & getrecommendations! Published in 2025 at "Biology"
DOI: 10.3390/biology14111622
Abstract: Simple Summary Predicting the genetic potential of animals and plants from their DNA can greatly accelerate breeding for traits such as growth, yield, or disease resistance. However, whole-genome sequencing produces extremely large datasets that are… read more here.
Keywords: method; deep autoencoder; whole genome; prediction ... See more keywords
Circulating Tumor DNA-Based Genomic Profiling Assays in Adult Solid Tumors for Precision Oncology: Recent Advancements and Future Challenges
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133275
Abstract: Simple Summary The use of liquid biopsy for tumor genomic profiling to identify genomic biomarkers for targeted therapies has revolutionized the clinical practice in oncology management. In this review, we have summarized the recent advancements… read more here.
Keywords: oncology; genomic profiling; recent advancements; based genomic ... See more keywords
Classification and Prognostic Stratification Based on Genomic Features in Myelodysplastic and Myeloproliferative Neoplasm- and Their Overlapping Conditions
Sign Up to like & getrecommendations! Published in 2024 at "Cancers"
DOI: 10.3390/cancers16234121
Abstract: Simple Summary We aimed to enhance the classification and prognostic prediction of myeloid neoplasms, which encompass diverse disease subtypes. Unsupervised clustering identified 10 genomic groups within myeloid neoplasms that correlated with distinct disease subtypes and… read more here.
Keywords: genomic features; stratification based; prognostic stratification; myeloid neoplasms ... See more keywords