VSS: Variance-stabilized signals for sequencing-based genomic signals.
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab457
Abstract: MOTIVATION A sequencing-based genomic assay such as ChIP-seq outputs a real-valued signal for each position in the genome that measures the strength of activity at that position. Most genomic signals lack the property of variance… read more here.
Keywords: stabilized signals; variance stabilized; genomic signals; variance ... See more keywords
Clinical utility of next-generation sequencing (NGS)-based genomic profiling of advanced solid tumors in routine clinical practice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e24157
Abstract: e24157Background: Next-generation sequencing (NGS)-based genomic profiling of advanced solid tumors has given a new perspective to personalized patient care in oncology. In a single run, NGS allows... read more here.
Keywords: sequencing ngs; ngs based; next generation; oncology ... See more keywords
Illustration of temporal evolution in patients with metastatic renal cell carcinoma (mRCC) using both circulating tumor DNA (ctDNA) and tissue-based genomic data.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.6_suppl.347
Abstract: 347Background: We have previously demonstrated the feasibility of ctDNA assessment in mRCC and preliminarily showed agreement between ctDNA and tissue-based genomic findings (Zengin et al ESMO 2020... read more here.
Keywords: tissue based; based genomic; ctdna; mrcc ... See more keywords
Circulating Tumor DNA-Based Genomic Profiling Assays in Adult Solid Tumors for Precision Oncology: Recent Advancements and Future Challenges
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133275
Abstract: Simple Summary The use of liquid biopsy for tumor genomic profiling to identify genomic biomarkers for targeted therapies has revolutionized the clinical practice in oncology management. In this review, we have summarized the recent advancements… read more here.
Keywords: oncology; genomic profiling; recent advancements; based genomic ... See more keywords