Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
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DOI: 10.1021/acs.orglett.1c03299
Abstract: A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media. Modulation of the amine pKa promotes fragmentation even… read more here.
Keywords: grob fragmentation; self immolative; based grob; fragmentation ... See more keywords