Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors
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DOI: 10.1021/acs.jmedchem.4c00836
Abstract: HDAC8 can mediate signals by using its enzymatic or nonenzymatic functions, which are expected to be critical for various types of cancer. Herein, we employed proteolysis targeting chimera (PROTAC) technology to target the enzymatic as… read more here.
Keywords: protacs treatment; exploration hydrazide; based hdac8; hydrazide based ... See more keywords