Ribonuclease-Based Immunotoxins as Anticancer Agents.
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DOI: 10.1002/bab.70046
Abstract: Ribonucleases (RNases) represent a distinct category of nucleases that facilitate RNA degradation into smaller components. These enzymes are particularly adept at dismantling RNA strands and other materials. A promising strategy for the targeted treatment of… read more here.
Keywords: cancer; anticancer agents; based immunotoxins; ribonuclease based ... See more keywords
Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins
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DOI: 10.3390/toxins11100593
Abstract: Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among… read more here.
Keywords: ribotoxin sarcin; furin cleavage; inclusion furin; cleavage site ... See more keywords