Methysticin Acts as a Mechanism-Based Inactivator of Cytochrome P450 2C9.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00098
Abstract: Methysticin is one of the naturally occurring bioactive constituents extracted from Piper methysticum Forst. In the present study, we intended to investigate the inhibitory effect of methysticin on cytochrome P450 (P450) enzymes. Methysticin exhibited time-,… read more here.
Keywords: mechanism based; cyp2c9; cytochrome p450; p450 ... See more keywords
Tofacitinib is a mechanism-based inactivator of cytochrome P450 3A4.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00141
Abstract: Tofacitinib (TFT) is an oral JAK inhibitor which has been approved for the treatment of moderately and severely active rheumatoid arthritis. TFT was found to show concentration-, time- and NADPH-dependent inhibition of CYP3A4, and irreversibility… read more here.
Keywords: tofacitinib; mechanism based; based inactivator; inactivation ... See more keywords