Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators.
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DOI: 10.1016/j.bioorg.2021.105427
Abstract: Despite the achieved progress in developing efficient MDM2-p53 protein-protein interaction inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators posed an argument about the druggability of the pathway. Combination studies disclosed… read more here.
Keywords: mdm2 inhibitors; based mdm2; p53; spirooxindole based ... See more keywords