Discovery of 1,6-naphthyridinone-based MET kinase inhibitor bearing quinoline moiety as promising antitumor drug candidate.
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DOI: 10.1016/j.ejmech.2020.112174
Abstract: A series of 1,6-naphthyridinone-based MET kinase inhibitors bearing quinoline moiety in block A were designed and synthesized based on the structures of Cabozantinib and our reported compound IV. Extensive SAR and DMPK studies led to… read more here.
Keywords: naphthyridinone based; kinase inhibitor; met kinase; based met ... See more keywords