Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00103
Abstract: Inhibitors of the proprotein convertase furin might serve as broad-spectrum antiviral therapeutics. High cellular potency and antiviral activity against acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported for (3,5-dichlorophenyl)pyridine-derived furin inhibitors. Here we characterized… read more here.
Keywords: inhibit furin; molecules inhibit; dichlorophenylpyridine based; mechanism ... See more keywords
Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes
Sign Up to like & getrecommendations! Published in 2018 at "Royal Society Open Science"
DOI: 10.1098/rsos.180564
Abstract: The design, synthesis and property characterization of new functional materials has garnered interest in a variety of fields. Materials that are capable of recognizing and binding with small molecules have applications in sensing, sequestration, delivery… read more here.
Keywords: hydrogen; materials based; based molecules; drug ... See more keywords
Potential triazole-based molecules for the treatment of neglected diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170727103901
Abstract: Neglected Diseases (NDs) affect million of people, especially the poorest population around the world. Several efforts to an effective treatment have proved insufficient at the moment. In this context, triazole derivatives have shown great relevance… read more here.
Keywords: triazole; based molecules; treatment; chemistry ... See more keywords
Recent developments in the Medicinal Chemistry and therapeutic potential of anti-cancer Protacs based molecules.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220803112409
Abstract: BACKGROUND PROTACs is an emerging technique that addresses the disease causing proteins by targeting protein degradation. PROTACs molecules are bifunctional small molecules that simultaneously bind to the protein of interest (POIs) and an E3 ligase… read more here.
Keywords: protacs molecules; protacs; medicinal chemistry; protacs based ... See more keywords
Quinoline-Based Molecules Targeting c-Met, EGF, and VEGF Receptors and the Proteins Involved in Related Carcinogenic Pathways
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DOI: 10.3390/molecules25184279
Abstract: The quinoline ring system has long been known as a versatile nucleus in the design and synthesis of biologically active compounds. Currently, more than one hundred quinoline compounds have been approved in therapy as antimicrobial,… read more here.
Keywords: met egf; targeting met; based molecules; molecules targeting ... See more keywords
Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27113613
Abstract: Novel 1,3,4-thiadiazole derivatives were synthesized through the reaction of methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate and the appropriate hydrazonoyl halides in the presence of a few drops of diisopropylethylamine. The chemical structure of the newly fabricated compounds was… read more here.
Keywords: molecular docking; thiadiazole based; molecules promising; based molecules ... See more keywords