Rational design of polymer-based mRNA delivery systems for cancer treatment
Sign Up to like & getrecommendations! Published in 2024 at "Polymer Chemistry"
DOI: 10.1039/d4py00206g
Abstract: Messenger RNA (mRNA)-based cancer therapeutics have shown great promise in cancer prevention and treatment, such as mRNA cancer vaccines and protein replacement therapeutics. The key to mRNA cancer therapeutics is... read more here.
Keywords: cancer; treatment; design polymer; based mrna ... See more keywords
A first-in-human study to evaluate a personalized neoantigen-based mRNA-loaded dendritic cell vaccine, in combination with ablation, in patients with hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e14513
Abstract: e14513 Background: Local recurrence of Hepatocellular Carcinoma (HCC) following potentially curative resection or ablation is an inevitable risk. T cells recognizing neoantigens are present in most cancers including HCC and offer a specific and highly… read more here.
Keywords: based mrna; neoantigen; ablation; cell ... See more keywords
Lipid nanoparticle-based mRNA vaccines in cancers: Current advances and future prospects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.922301
Abstract: Messenger RNA (mRNA) vaccines constitute an emerging therapeutic method with the advantages of high safety and efficiency as well as easy synthesis; thus, they have been widely used in various human diseases, especially in malignant… read more here.
Keywords: vaccines cancers; lipid nanoparticle; mrna vaccines; based mrna ... See more keywords
A prognostic estimation model based on mRNA-sequence data for patients with oligodendroglioma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1074593
Abstract: Background The diagnosis of oligodendroglioma based on the latest World Health Organization Classification of Tumors of the Central Nervous System (WHO CNS 5) criteria requires the codeletion of chromosome arms 1p and 19q and isocitrate… read more here.
Keywords: based mrna; mrna sequence; patients oligodendroglioma; model ... See more keywords