Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113391
Abstract: CDK8 is deregulated in multiple types of human cancer and is viewed as a therapeutic target for the treatment of the disease. Accordingly, the search for small-molecule inhibitors of CDK8 is being intensified. Capitalising on… read more here.
Keywords: inhibitor; based optimisation; cdk8; structure based ... See more keywords
Simulation-based optimisation of maintenance systems: Industrial case studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Manufacturing Systems"
DOI: 10.1016/j.jmsy.2017.05.008
Abstract: Abstract Investigating the optimum blend of maintenance strategies for a given manufacturing system is a continuing concern amongst maintenance academics and professionals. Recent evidence suggests that little research is conducted on the simulation optimisation of… read more here.
Keywords: maintenance; simulation based; based optimisation; case studies ... See more keywords
Tolerance allocation: A reliability based optimisation approach
Sign Up to like & getrecommendations! Published in 2020 at "Procedia Manufacturing"
DOI: 10.1016/j.promfg.2020.10.146
Abstract: Abstract Tolerance analysis and allocation are two activities of great importance in product development. The mathematical formulation of the latter concerns the establishment and solution of a constraint optimisation problem. In this work, making one… read more here.
Keywords: tolerance; reliability based; based optimisation; optimisation ... See more keywords
Simulation-based optimisation of a linear Fresnel collector mirror field and receiver for optical, thermal and economic performance
Sign Up to like & getrecommendations! Published in 2017 at "Solar Energy"
DOI: 10.1016/j.solener.2017.06.001
Abstract: The University of Pretoria (South Africa) and the South African National Research Foundation (DST-NRF Solar Spoke). read more here.
Keywords: collector mirror; fresnel collector; optimisation linear; simulation based ... See more keywords
Precision dosing‐based optimisation of paroxetine during pregnancy for poor and ultrarapid CYP2D6 metabolisers: a virtual clinical trial pharmacokinetics study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13281
Abstract: Paroxetine has been demonstrated to undergo gestation‐related reductions in plasma concentrations, to an extent which is dictated by the polymorphic state of CYP 2D6. However, knowledge of appropriate dose titrations is lacking. read more here.
Keywords: paroxetine pregnancy; dosing based; optimisation paroxetine; precision dosing ... See more keywords