Development of cancer immunotherapy based on PD-1/PD-L1 pathway blockade
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DOI: 10.1039/c9ra04590b
Abstract: The possible reasons that caused low response rate and severe side effects of programmed death receptor 1 (PD-1)/programmed death ligand 1 (PD-L1) blockade therapy and corresponding strategies. read more here.
Keywords: pathway blockade; immunotherapy based; development cancer; cancer immunotherapy ... See more keywords
GWAS summary-based pathway analysis correcting for the genetic confounding impact of environmental exposures
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DOI: 10.1093/bib/bbx025
Abstract: Genome-wide association study (GWAS)-based pathway association analysis is a powerful approach for the genetic studies of human complex diseases. However, the genetic confounding effects of environment exposure-related genes can decrease the accuracy of GWAS-based pathway… read more here.
Keywords: analysis; environmental exposures; genetic confounding; gwas summary ... See more keywords
Ubiquitin-based pathway acts inside chloroplasts to regulate photosynthesis
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DOI: 10.1101/2022.06.06.494369
Abstract: Photosynthesis is the energetic basis for most life on Earth, and in plants it operates inside double-membrane-bound organelles called chloroplasts. The photosynthetic apparatus comprises numerous proteins encoded by the nuclear and organellar genomes. Maintenance of… read more here.
Keywords: ubiquitin based; acts inside; inside chloroplasts; photosynthesis ... See more keywords
Implementation of a Phenobarbital-based Pathway for Severe Alcohol Withdrawal: A Mixed-Methods Study.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the American Thoracic Society"
DOI: 10.1513/annalsats.202102-121oc
Abstract: RATIONALE Several institutions have implemented phenobarbital-based pathways for the treatment of alcohol withdrawal syndrome. However, little is known about the care processes, effectiveness, and safety of phenobarbital-based pathways for intensive care unit patients. OBJECTIVES This… read more here.
Keywords: phenobarbital based; alcohol withdrawal; based pathway;
Exploring autophagy-related prognostic genes of Alzheimer’s disease based on pathway crosstalk analysis
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DOI: 10.17305/bjbms.2021.7019
Abstract: Recent studies have shown that different signaling pathways are involved in the pathogenesis of Alzheimer’s disease (AD), with complex molecular connections existing between these pathways. Autophagy is crucial for the degradation and production of pathogenic… read more here.
Keywords: prognostic genes; alzheimer disease; pathway crosstalk; analysis ... See more keywords